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An evolutionarily conserved Rit GTPase–p38 MAPK signaling pathway mediates oxidative stress resistance

By Weikang Cai, Jennifer L. Rudolph, Susan M. W. Harrison, Ling Jin, Aubrey L. Frantz, Douglas A. Harrison and Douglas A. Andres


Rit knockout mice and D-Ric null Drosophila were used to identify the Rit/RIC subfamily of Ras-related GTPases as regulators of an evolutionarily conserved, p38-dependent signaling cascade that functions as a survival mechanism for cells in response to reactive oxygen species exposure

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Publisher: The American Society for Cell Biology
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Provided by: PubMed Central
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