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The testis-specific Cα2 subunit of PKA is kinetically indistinguishable from the common Cα1 subunit of PKA

By Maike M Vetter, Hans-M Zenn, Eva Méndez, Heidrun van den Boom, Friedrich W Herberg and Bjørn S Skålhegg
Topics: Research Article
Publisher: BioMed Central
OAI identifier: oai:pubmedcentral.nih.gov:3163529
Provided by: PubMed Central

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  1. A conserved deamidation site at Asn 2 in the catalytic subunit of mammalian cAMP-dependent protein kinase detected by capillary LC-MS and tandem mass spectrometry. Protein Sci 87:457-469,
  2. (1982). Adenosine cyclic 3’,5’-monophosphate dependent protein kinase: kinetic mechanism for the bovine skeletal muscle catalytic subunit. Biochemistry
  3. (1995). Aderem A: The myristoyl-electrostatic switch: a modulator of reversible protein-membrane interactions. Trends Biochem Sci
  4. (1993). Cellular location and age-dependent changes of the regulatory subunits of cAMP-dependent protein kinase in rat testis.
  5. (1988). Cloning of cDNA for the catalytic subunit of cAMP-dependent protein kinase. Methods Enzymol
  6. (1996). Cyclic AMP-dependent protein kinase (cAK) in human B cells: co-localization of type I cAK (RI alpha 2 C2) with the antigen receptor during anti-immunoglobulin-induced B cell activation.
  7. (1992). Cyclic AMP-dependent protein kinase type I mediates the inhibitory effects of 3’,5’-cyclic adenosine monophosphate on cell replication in human T lymphocytes.
  8. (1986). Cyclic nucleotide-dependent protein kinases.Edited by:
  9. (1989). Differential expression and subcellular localization for subunits of cAMPdependent protein kinase during ram spermatogenesis.
  10. (1994). Differential localization of two isoforms of the regulatory subunit RII alpha of cAMP-dependent protein kinase in human sperm: biochemical and cytochemical study. Mol Reprod Dev
  11. (2002). E: Protein kinase A associates with HA95 and affects transcriptional coactivation by EpsteinBarr virus nuclear proteins. Mol Cell Biol
  12. (1965). EW: Adenosine 3’,5’-monophosphate in biological materials. II. The measurement of adenosine 3’,5’-monophosphate in tissues and the role of the cyclic nucleotide in the lipolytic response of fat to epinephrine.
  13. (2001). GB: Differential expression of the C(s) and Calpha1 isoforms of the catalytic subunit of cyclic 3’,5’-adenosine monophosphate-dependent protein kinase testicular cells. Biol Reprod
  14. (1998). GB: The catalytic subunit of the cAMP-dependent protein kinase of ovine sperm flagella has a unique amino-terminal sequence.
  15. (1989). GS: A mutation in the catalytic subunit of protein kinase A prevents myristylation but does not inhibit biological activity.
  16. (1999). GS: Deletion of type IIalpha regulatory subunit delocalizes protein kinase A in mouse sperm without affecting motility or fertilization.
  17. (1986). GS: Evidence for a second isoform of the catalytic subunit of cAMP-dependent protein kinase.
  18. (2000). GS: Expression of a nonmyristylated variant of the catalytic subunit of protein kinase A during male germcell development. Proc Natl Acad Sci USA
  19. (1987). GS: Inhibition of intracellular cAMP-dependent protein kinase using mutant genes of the regulatory type I subunit.
  20. (1986). GS: Isolation of cDNA clones coding for the catalytic subunit of mouse cAMP-dependent protein kinase. Proc Natl Acad Sci USA
  21. (2004). GS: Sperm-specific protein kinase A catalytic subunit Calpha2 orchestrates cAMP signaling for male fertility. Proc Natl Acad Sci USA
  22. (2002). GS: The essential role of RI alpha in the maintenance of regulated PKA activity.
  23. (1997). GS: Two novel brain-specific splice variants of the murine Cbeta gene of cAMP-dependent protein kinase.
  24. (2009). Herberg FW: Chemical tools selectively target components of the PKA system.
  25. (2004). Herberg FW: Determination of kinetic data using surface plasmon resonance biosensors. Methods Mol Med
  26. (2005). Herberg FW: Direct optical detection of protein-ligand interactions. Methods Mol Biol
  27. (2008). Herberg FW: Effect of metal ions on high-affinity binding of pseudosubstrate inhibitors to PKA.
  28. (2007). Herberg FW: Molecular basis for isoform-specific autoregulation of protein kinase A. Cellular Signalling
  29. (1999). Herberg FW: PrKX is a novel catalytic subunit of the cAMP-dependent protein kinase regulated by the regulatory subunit type I.
  30. (1997). Idzerda RL, McKnight GS: Compensatory regulation of RIalpha protein levels in protein kinase A mutant mice.
  31. (1996). Idzerda RL: Impaired hippocampal plasticity in mice lacking the Cbeta1 catalytic subunit of cAMP-dependent protein kinase.
  32. (2000). Intracellular distribution of mammalian protein kinase A catalytic subunit altered by conserved Asn2 deamidation.
  33. (1991). Lundström I: Quantitative determination of surface concentration of protein with surface plasmon resonance using radio labeled proteins. Sensors and Actuators B: Chemical
  34. (1989). MD: Affinity purification of the C alpha and C beta isoforms of the catalytic subunit of cAMP-dependent protein kinase.
  35. (1996). MD: The major catalytic subunit isoforms of cAMP-dependent protein kinase have distinct biochemical properties in vitro and in vivo.
  36. (1999). Mobilization of the A-kinase N-myristate through an isoform-specific intermolecular switch. Proc Natl Acad Sci USA
  37. (1990). Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis–representing a third isoform for the catalytic subunit of cAMPdependent protein kinase. Mol Endocrinol
  38. (2001). MP: Two distinct caveolin-1 domains mediate the functional interaction of caveolin-1 with protein kinase A. Am J Physiol Cell Physiol
  39. (2002). Mutation of the Calpha subunit of PKA leads to growth retardation and sperm dysfunction. Mol Endocrinol
  40. (1996). Myristoylated and non-myristoylated forms of the pH sensor protein hisactophilin II: intracellular shuttling to plasma membrane and nucleus monitored in real time by a fusion with green fluorescent protein.
  41. (1993). Phosphotransferase and substrate binding mechanism of the cAMPdependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5-24).
  42. (2003). PKA phosphorylates the p75 receptor and regulates its localization to lipid rafts.
  43. (1991). Pyerin W: Isoform C beta 2, an unusual form of the bovine catalytic subunit of cAMP-dependent protein kinase.
  44. (1991). SJ: Identification, characterization, and hormonal regulation of 3’,5 ’-cyclic adenosine monophosphate-dependent protein kinases in rat Sertoli cells. Endocrinology
  45. (2000). Skålhegg BS: A novel isoform of human cyclic 3’,5’-adenosine monophosphatedependent protein kinase, c alpha-s, localizes to sperm midpiece. Biol Reprod
  46. (2005). Skålhegg BS: Identification and characterization of novel PKA holoenzymes in human T lymphocytes.
  47. (2001). Skålhegg BS: Identification of novel splice variants of the human catalytic subunit Cbeta of cAMP-dependent protein kinas.
  48. (2006). Skålhegg BS: Identification, cloning and characterization of a novel 47 kDa murine PKA C subunit homologous to human and bovine Cbeta2. BMC Biochem
  49. (2008). Skålhegg BS: Inactive forms of the catalytic subunit of protein kinase A are expressed in the brain of higher primates.
  50. (2004). Skålhegg BS: Induction of Cbeta splice variants and formation of novel forms of protein kinase A type II holoenzymes during retinoic acid-induced differentiation of human NT2 cells. Cell Signal
  51. (2007). Skålhegg BS: Involvement of the catalytic subunit of protein kinase A and of HA95 in pre-mRNA splicing. Exp Cell Res
  52. (2009). Skålhegg BS: Isoform-specific regulation of immune cell reactivity by the catalytic subunit of protein kinase A (PKA). Cell Signal
  53. (1991). Sowadski JM: Crystallization of catalytic subunit of adenosine cyclic monophosphate-dependent protein kinase. Methods Enzymol
  54. (2005). SS: A-kinase-interacting protein localizes protein kinase A in the nucleus. Proc Natl Acad Sci USA
  55. (1997). SS: Autophosphorylation of the catalytic subunit of cAMP-dependent protein kinase in Escherichia coli. Protein Eng
  56. (1992). SS: Autophosphorylation of the catalytic subunit of cAMP-dependent protein kinase.
  57. (1994). SS: Crosstalk between domains in the regulatory subunit of cAMP-dependent protein kinase: Vetter et al.
  58. (1997). SS: Dissecting the cooperative reassociation of the regulatory and catalytic subunits of cAMP-dependent protein kinase. Role of Trp-196 in the catalytic subunit.
  59. (1999). SS: Dissection of the nucleotide and metal-phosphate binding sites in cAMP-dependent protein kinase. Biochemistry
  60. (1978). Studies on the properties and mode of action of the purified regulatory subunit of bovine heart adenosine 3’:5’-monophosphate-dependent protein kinase.
  61. (1997). Tasken K: Selective activation of cAMP-dependent protein kinase type I inhibits rat natural killer cell cytotoxicity.
  62. (2000). Tasken K: Specificity in the cAMP/PKA signaling pathway. Differential expression, regulation, and subcellular localization of subunits of PKA. Front Biosci
  63. (1998). Tasken K: The gene encoding the C gamma catalytic subunit of cAMPdependent protein kinase is a transcribed retroposon. Genomics
  64. (1989). Taylor SS: Expression of the catalytic subunit of cAMPdependent protein kinase in Escherichia coli.
  65. (1997). Taylor SS: Importance of the Ahelix of the catalytic subunit of cAMP-dependent protein kinase for stability and for orienting subdomains at the cleft interface. Protein Sci
  66. (1993). Taylor SS: Physiological inhibitors of the catalytic subunit of cAMP-dependent protein kinase: effect of MgATP on protein-protein interactions. Biochemistry
  67. (1994). The cAMP-dependent protein kinases and cAMP signal transduction. Semin Cancer Biol
  68. (2000). The protein kinase A catalytic subunit Cbeta2: molecular characterization and distribution of the splice variant.
  69. (1997). The transcriptional activity of NF-kappaB is regulated by the IkappaBassociated PKAc subunit through a cyclic AMP-independent mechanism. Cell