Article thumbnail

Molecular characterization of cathepsin B from Clonorchis sinensis excretory/secretory products and assessment of its potential for serodiagnosis of clonorchiasis

By Wenjun Chen, Xiaoyun Wang, Xuerong Li, Xiaoli Lv, Chenhui Zhou, Chuanhuan Deng, Huali Lei, Jingtao Men, Yongxiu Fan, Chi Liang and Xinbing Yu
Topics: Research
Publisher: BioMed Central
OAI identifier:
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles


  1. (2008). A: A family of cathepsin B cysteine proteases expressed in the gut of the human hookworm, Necator americanus. Mol Biochem Parasitol
  2. (2008). AG: The silencing of cysteine proteases in Fasciola hepatica newly excysted juveniles using RNA interference reduces gut penetration.
  3. (2010). BK: A family of cathepsin F cysteine proteases of Clonorchis sinensis is the major secreted proteins that are expressed in the intestine of the parasite. Mol Biochem Parasitol
  4. (2010). Bovipain-2, the falcipain-2 ortholog, is expressed in intraerythrocytic stages of the tick-transmitted hemoparasite Babesia bovis. Parasit Vectors
  5. (2007). Caffrey CR: Schistosomiasis mansoni: novel chemotherapy using a cysteine protease inhibitor. PLoS Med
  6. (2006). Critical roles for excretory-secretory cysteine proteases during tissue invasion of Paragonimus westermani newly excysted metacercariae. Cell Microbiol
  7. (2002). DS: A novel cathepsin B active site motif is shared by helminth bloodfeeders. Exp Parasitol
  8. (2008). Duce IR: Developing novel anthelmintics from plant cysteine proteinases. Parasit Vectors
  9. (2005). EJ: Long-term suppression of cathepsin B levels by RNA interference retards schistosome growth. Mol Biochem Parasitol
  10. (2004). Erlich R: A review and update on cholangiocarcinoma. Oncology
  11. (2010). et al: Characterization of proteinases from the midgut of Rhipicephalus (Boophilus) microplus involved in the generation of antimicrobial peptides. Parasit Vectors
  12. (2009). et al: Identification of a serodiagnostic antigen, legumain, by immunoproteomic analysis of excretory-secretory products of Clonorchis sinensis adult worms. Proteomics
  13. (2007). et al: Liver fluke induces cholangiocarcinoma. PLoS Med
  14. (2005). Fang YY: Clonorchiasis: a key foodborne zoonosis in China. Lancet Infect Dis
  15. (2010). Hennequin C: Evaluation of a rapid enzymelinked immunosorbent assay for diagnosis of strongyloidiasis.
  16. (2010). Hong ST: Epidemiology of cholangiocarcinoma: an update focusing on risk factors. Cancer Sci
  17. (2005). Hong ST: The identification of a Clonorchis sinensis gene encoding an antigenic egg protein. Parasitol Res
  18. (2004). Hong ST: The involvement of the cysteine proteases of Clonorchis sinensis metacercariae in excystment. Parasitol Res
  19. (2004). Hotez PJ: Vaccination of dogs with a recombinant cysteine protease from the intestine of canine hookworms diminishes the fecundity and growth of worms.
  20. JB: Spatial epidemiology in zoonotic parasitic diseases: insights gained at
  21. (1997). JS: Role of the occluding loop in cathepsin B activity.
  22. (2003). Khaznadji E, et al: Fasciola hepatica cathepsin L-like proteases: biology, function, and potential in the development of first generation liver fluke vaccines.
  23. (2004). Kong Y: A cathepsin F of adult Clonorchis sinensis and its phylogenetic conservation in trematodes. Parasitology
  24. (2008). Kopacek P: Profiling of proteolytic enzymes in the gut of the tick Ixodes ricinus reveals an evolutionarily conserved network of aspartic and cysteine peptidases. Parasit Vectors
  25. (2011). Laha T: Evaluation of liver fluke recombinant cathepsin B-1 protease as a serodiagnostic antigen for human opisthorchiasis. Parasitol Int
  26. (2005). Lymbery AJ: Fish-borne parasitic zoonoses: status and issues.
  27. (2002). McKerrow JH: Cysteine proteases of parasitic organisms. Mol Biochem Parasitol
  28. (2007). Molecular characterization and serodiagnosis analysis of a novel lysophospholipase from Clonorchis sinensis. Parasitol Res
  29. (2009). Molecular cloning and analysis of stage and tissue-specific expression of Cathepsin L-like protease from Clonorchis sinensis. Parasitol Res
  30. (2004). Molecular expression of a cysteine proteinase of Clonorchis sinensis and its application to an enzyme-linked immunosorbent assay for immunodiagnosis of clonorchiasis. Clin Diagn Lab Immunol
  31. (2003). Pathobiology of opisthorchiasis: an update. Acta Trop
  32. (2007). PM: Comparative proteomics of excretory-secretory proteins released by the liver fluke Fasciola hepatica in sheep host bile and during in vitro culture ex host. Mol Cell Proteomics
  33. (2006). Sajid M: Proteases in parasitic diseases. Annu Rev Pathol
  34. (2009). Seo SB: Differential gene expression profiling in human cholangiocarcinoma cells treated with Clonorchis sinensis excretory-secretory products. Parasitol Res
  35. (2004). Sobhon P: Molecular cloning and analysis of stage and tissue-specific expression of cathepsin B encoding genes from Fasciola gigantica. Mol Biochem Parasitol
  36. (2010). Spithill TW: Cathepsin B proteases of flukes: the key to facilitating parasite control? Trends Parasitol
  37. (2006). Spithill TW: Production and processing of a recombinant Fasciola hepatica cathepsin B-like enzyme (FhcatB1) reveals potential processing mechanisms in the parasite. Biol Chem
  38. (2003). Suppression of cathepsin B expression in Schistosoma mansoni by RNA interference.
  39. (2002). TS: Expression of cysteine proteinase of Clonorchis sinensis and its use in serodiagnosis of clonorchiasis.
  40. (2001). WJ: Early immunodiagnosis of fasciolosis in ruminants using recombinant Fasciola hepatica cathepsin L-like protease.
  41. (2009). X: Experimental model in rats for study on transmission dynamics and evaluation of Clonorchis sinensis infection immunologically, morphologically, and pathologically. Parasitol Res
  42. (2009). X: Molecular characterization of a novel Clonorchis sinensis secretory phospholipase A(2) and investigation of its potential contribution to hepatic fibrosis. Mol Biochem Parasitol
  43. (2009). YM: Resistance of cholangiocarcinoma cells to parthenolide-induced apoptosis by the excretory-secretory products of Clonorchis sinensis. Parasitol Res
  44. (2006). Yong TS: Vaccination with DNA encoding cysteine proteinase confers protective immune response to rats infected with Clonorchis sinensis. Vaccine