Article thumbnail

Aconitase Regulation of Erythropoiesis Correlates with a Novel Licensing Function in Erythropoietin-Induced ERK Signaling

By Anne-Laure Talbot, Grant C. Bullock, Lorrie L. Delehanty, Martin Sattler, Zhizhuang Joe Zhao and Adam N. Goldfarb
Topics: Research Article
Publisher: Public Library of Science
OAI identifier:
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles


  1. (2010). A Key Commitment Step
  2. (2008). A Mitochondrial Kinase Complex Is Essential to Mediate an ERK1/2-Dependent Phosphorylation of a Key Regulatory Protein in Steroid Biosynthesis.
  3. (2009). A New Paradigm for MAPK: Structural Interactions of hERK1 with Mitochondria in HeLa Cells.
  4. (2002). Absence of erythrogenesis and vasculogenesis in Plcg1-deficient mice.
  5. (2007). Activation of aconitase in mouse fast-twitch skeletal muscle during contractionmediated oxidative stress.
  6. (2005). Active ERK1 is dimerized in vivo: bisphosphodimers generate peak kinase activity and monophosphodimers maintain basal ERK1 activity.
  7. (2009). Advances in Understanding and Management of Myeloproliferative Neoplasms. CA: A Cancer Journal for Clinicians 59: 171–191. Regulation of Erythropoiesis by Aconitase Enzymes PLoS
  8. (2006). AMP-activated protein kinase– development of the energy sensor concept.
  9. (2010). Analysis of ERKs’ Dimerization by Electrophoresis MAP Kinase Signaling Protocols:
  10. (1996). Analysis of mitochondrial morphology and function with novel fixable fluorescent stains.
  11. BioGRID: a general repository for interaction datasets.
  12. (1999). Chloramphenicol-induced mitochondrial dysfunction is associated with decreased transferrin receptor expression and ferritin synthesis in K562 cells and is unrelated to IRE-IRP interactions.
  13. (2005). Co-operative signalling mechanisms required for erythroid precursor expansion in response to erythropoietin and stem cell factor.
  14. (2004). Constitutive activation of the MEK/ERK pathway mediates all effects of oncogenic H-ras expression in primary erythroid progenitors.
  15. (2003). Development of Novel Fluorescence Probes That Can Reliably Detect Reactive Oxygen Species and Distinguish Specific Species.
  16. (2011). Differential biological activity of diseaseassociated JAK2 mutants.
  17. (2000). Effects of erythropoietin on platelet reactivity and thrombopoiesis in humans.
  18. (2009). Erythroid dysplasia, megaloblastic anemia, and impaired lymphopoiesis arising from mitochondrial dysfunction.
  19. (2006). Erythroid inhibition by the leukemic fusion AML1-ETO is associated with impaired acetylation of the major erythroid transcription factor GATA-1.
  20. (1982). Erythropoiesis, erythropoietin, and iron.
  21. (2005). Erythropoietin receptor Y479 couples to ERK1/2 activation via recruitment of phospholipase C[gamma].
  22. (2009). Erythropoietin-induced phosphorylation/degradation of BIM contributes to survival of erythroid cells.
  23. (2000). Erythropoietin, iron, and erythropoiesis.
  24. (2008). Essential role of ERK dimers in the activation of cytoplasmic but not nuclear substrates by ERK-scaffold complexes.
  25. (2004). Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis.
  26. (1986). Hematopoiesis in the rat: quantitation of hematopoietic progenitors and the response to iron deficiency anemia.
  27. (2007). Increased plasma transferrin, altered body iron distribution, and microcytic hypochromic anemia in ferrochelatase-deficient mice.
  28. (2001). Ineffective erythropoiesis in Stat5a(2/2)5b(2/2) mice due to decreased survival of early erythroblasts.
  29. (2010). Iron control of erythroid development by a novel aconitase-associated regulatory pathway.
  30. (2004). Jun Blockade of Erythropoiesis: Role for Repression of GATA-1 by HERP2.
  31. (1999). Kolonics A
  32. (2002). Localization of the MP1-MAPK Scaffold Complex to Endosomes Is Mediated by p14 and Required for Signal Transduction.
  33. (2007). Metabolic regulation of citrate and iron by aconitases: role of iron-sulfur cluster biogenesis.
  34. (2004). Mitochondrial extracellular signal-regulated kinases 1/2 (ERK1/2) are modulated during brain development.
  35. (2001). Modulation of mitochondrial function by hydrogen peroxide.
  36. (1997). Nuclear translocation of mitogen-activated protein kinase kinase (MEK1) in response to mitogenic stimulation.
  37. (2007). Pathogenic mitochondrial DNA-induced respiration defects in hematopoietic cells result in anemia by suppressing erythroid differentiation.
  38. (2004). PI3 kinase is important for Ras, MEK and Erk activation of Epo-stimulated human erythroid progenitors.
  39. (2006). PI3K/Akt-dependent Epo-induced signalling and target genes in human early erythroid progenitor cells.
  40. (2002). Polycythemia vera: myths, mechanisms, and management.
  41. (2010). Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms.
  42. (2009). Ras Subcellular Localization Defines Extracellular Signal-Regulated Kinase 1 and 2 Substrate Specificity through Distinct Utilization of Scaffold Proteins.
  43. (2008). Rb intrinsically promotes erythropoiesis by coupling cell cycle exit with mitochondrial biogenesis.
  44. (1992). Reciprocal control of RNA-binding and aconitase activity in the regulation of the ironresponsive element binding protein: role of the iron-sulfur cluster.
  45. (2002). Regulation of erythropoietin-induced STAT serine phosphorylation by distinct mitogenactivated protein kinases.
  46. (2009). Regulation of mitochondrial aconitase by phosphorylation in diabetic rat heart.
  47. (2009). Resolving the distinct stages in erythroid differentiation based on dynamic changes in membrane protein expression during erythropoiesis.
  48. (1990). Reticulocyte counting using flow cytometry.
  49. (2003). Scansite 2.0: proteome-wide prediction of cell signaling interactions using short sequence motifs.
  50. (2004). Sef Is a Spatial Regulator for Ras/MAP Kinase Signaling.
  51. (2006). Signals for stress erythropoiesis are integrated via an erythropoietin receptorphosphotyrosine-343-Stat5 axis.
  52. (2005). The anaemia of cancer: death by a thousand cuts.
  53. (2008). The Jak2V617F oncogene associated with myeloproliferative diseases requires a functional FERM domain for transformation and for expression of the Myc and Pim proto-oncogenes.
  54. (2010). The MAPK ERK1 is a negative regulator of the adult steady-state splenic erythropoiesis.
  55. (2007). The MEK/ERK cascade: from signaling specificity to diverse functions.
  56. (1996). The reaction of fluorocitrate with aconitase and the crystal structure of the enzymeinhibitor complex.
  57. (1997). The Role of Tyrosine Phosphorylation in Proliferation and Maturation of Erythroid Progenitor Cells.
  58. (2008). The RSK family of kinases: emerging roles in cellular signalling.
  59. (1984). Toxic characteristics of fluorocitrate, the toxic metabolite of compound 1080.
  60. (2006). Toxicology of fluoroacetate: a review, with possible directions for therapy research.
  61. (2008). Transgenic expression of JAK2V617F causes myeloproliferative disorders in mice.
  62. (2007). Unrestrained erythroblast development in Nix2/2 mice reveals a mechanism for apoptotic modulation of erythropoiesis.
  63. (2008). Wintrobe’s Clinical Hematology.
  64. (2007). Yeast aconitase binds and provides metabolically coupled protection to mitochondrial DNA.