Article thumbnail

Bone Marrow Micrometastases in Breast Cancer Patients: A Long-Term Follow-up Study

By Annamaria Molino, Monica Giovannini, Rocco Micciolo, Alessandra Auriemma, Elena Fiorio, Antonio Santo and Gian Luigi Cetto

Abstract

In 125 early breast cancer patients who underwent multiple bone marrow aspirates, there was no significant difference in terms of disease-free and overall survival after a median follow-up of 163 months between the patients with or without micrometastasis at the time of primary surgery. However, when the time-dependent evolution of the bone marrow aspirates was taken into account, some evidence for a longer disease-free and overall survival was found for the patients with negative bone marro

Topics: Brief Communication
Publisher: Libertas Academica
OAI identifier: oai:pubmedcentral.nih.gov:3161681
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles

Citations

  1. (1991). A comparative analysis of three different techniques for the detection of breast cancer cells in bone marrow.
  2. (2005). A pooled analysis of bone marrow micrometastasis in breast cancer.
  3. (2006). Bone marrow cells in the ‘pre-metastatic niche’: within bone and beyond.
  4. (1997). Bone marrow micrometastases in 109 breast cancer patients: correlation with clinical and pathological features and prognosis. Breast Cancer Res.
  5. (1999). Bone marrow micrometastases in breast cancer patients. Breast Cancer Res.
  6. (1991). Bone marrow micrometastases in primary breast cancer: prognostic signifi cance after 6 years’ follow-up.
  7. (2005). Breast cancer metastasis: Markers and models. Nature Reviews.
  8. (1991). Breast cancer micrometastases (BMM) in bone marrow: detection by fl uoresceinlabeled monoclonal antibodies (MABS) predicts early relapse.
  9. (1982). Cox’s regression model for counting processes, a large sample study.
  10. (1991). Detection of bone marrow micrometastases in patients with early-stage breast cancer.
  11. (1992). Detection of tumor cells in bone marrow of patients with primary breast cancer: a prognostic factor for distant metastasis.
  12. (2006). Disseminated tumor cells in breast cancer: detection, characterization and clinical relevance.
  13. (1990). Immunocytochemical detection of tumor cells in bone marrow in patients with primary breast cancer.
  14. (1994). Immunodetection of bone marrow micrometastases in breast carcinoma patients and its correlation with primary tumor prognostic features.
  15. (1986). Improvement of tumor cell detection using a pool of monoclonal antibodies.
  16. (1987). Micrometastases in bone marrow in patients with primary breast cancer: evaluation as an early predictor of bone metastases.
  17. (1991). Micrometastases in Breast Cancer: Long-term Follow-up of the First Patient Cohort.
  18. (1958). Nonparametric estimation from incomplete observations.
  19. (1997). of Clinical Oncology,
  20. (1991). Prediction of early relapse in patients with operable breast cancer by detection of occult bone marrow micrometastases.
  21. (2005). Prognostic relevance of disseminated tumor cells in the bone marrow and biological factors of 265 primary breast carcinomas.
  22. (2006). Prognostic signifi cance of disseminated tumor cells as detected by quantitative real-time reverse-transcriptase polymerase chain reaction in patients with breast cancer.
  23. (2006). Real-time RT-PCR. detection of disseminated tumour cells in bone marrow has superior prognostic signifi cance in comparison with circulating tumour cells in patients with breast cancer.
  24. (2006). Recent translational research: circulating tumor cells in breast cancer patients.
  25. (1972). Regression model and life tables (with discussion).
  26. (2006). Signifi cance, detection and markers of disseminated breast cancer cells.
  27. (2007). The clinical signifi cance of disseminated tumor cells in breast cancer.
  28. (1990). The prognostic signifi cance of marrow micrometastases in women with early breast cancer.
  29. (1994). The relationship between micrometastases in the bone marrow, histopathologic features of the primary tumor in breast cancer and prognosis.
  30. (1997). The signifi cance of tumor contamination in the bone marrow from high-risk primary breast cancer patients treated with high-dose chemotherapy and hematopoietic support.
  31. (2005). The value of bone marrow aspirates culture for the detection of bone marrow micrometastasis in breast cancer.
  32. (1994). Tumor cell detection in the bone marrow of breast cancer patients at primary therapy: results of a 3-year median follow-up.
  33. (1990). Use of Monoclonal Antibody MBr1 to Detect Micrometastases in Bone Marrow Specimens of Breast Cancer Patients.