(2010). A: The Pfam protein families database. Nucleic Acids Res
(2003). Aggarwal AK: Model of the brain tumor-Pumilio translation repressor complex. Genes Dev
(2007). al: Ensembl 2007. Nucleic Acids Res
(2004). Alber T: Sensor domain of the Mycobacterium tuberculosis receptor Ser/Thr protein kinase, PknD, forms a highly symmetric beta propeller.
(2001). Ballabio A: The tripartite motif family identifies cell compartments.
(2001). Chothia C: Assignment of homology to genome sequences using a library of hidden Markov models that represent all proteins of known structure.
(2009). Ciechanover A: Targeting proteins for destruction by the ubiquitin system: implications for human pathobiology. Annu Rev Pharmacol Toxicol
(2009). Conservation of the glucan phosphatase laforin is linked to rates of molecular evolution and the glucan metabolism of the organism.
(2006). Cox TC: Subclassification of the RBCC/TRIM superfamily reveals a novel motif necessary for microtubule binding.
(1999). de Cordoba SR: A novel protein tyrosine phosphatase gene is mutated in progressive myoclonus epilepsy of the Lafora type (EPM2). Human Mol Genet
(2002). Depiereux E: ESyPred3D: Prediction of proteins 3D structures. Bioinformatics
(2009). DJ: TRIM32 is an E3 ubiquitin ligase for dysbindin. Human Mol Genet
(2008). Genomic analysis of the TRIM family reveals two groups of genes with distinct evolutionary properties.
(2007). Guinovart JJ: Mechanism suppressing glycogen synthesis in neurons and its demise in progressive myoclonus epilepsy. Nat Neurosci
(2008). HC: TRIM family proteins and their emerging roles in innate immunity. Nat Rev Immunol
(2005). Insights into Lafora disease: malin is an E3 ubiquitin ligase that ubiquitinates and promotes the degradation of laforin. Proc Natl Acad Sci USA
(2007). JE: The phosphatase laforin crosses evolutionary boundaries and links carbohydrate metabolism to neuronal disease.
(2009). Joazeiro CA: RING domain E3 ubiquitin ligases. Annu Rev Biochem
(2009). Knoblich JA: The TRIM-NHL protein TRIM32 activates microRNAs and prevents self-renewal in mouse neural progenitors. Cell
(2009). Lafora progressive myoclonus epilepsy: a metaanalysis of reported mutations in the first decade following the discovery of the EPM2A and NHLRC1 genes. Hum Mutat
(2008). Malin decreases glycogen accumulation by promoting the degradation of protein targeting to glycogen (PTG).
(2005). MJ: Trim32 is a ubiquitin ligase mutated in limb girdle muscular dystrophy type 2H that binds to skeletal muscle myosin and ubiquitinates actin.
(2008). Mutations that impair interaction properties of TRIM32 associated with limb-girdle muscular dystrophy 2H. Hum Mutat
(2004). Only six kingdoms of life. Proc Biol Sci
P: AMP-activated protein kinase phosphorylates R5/PTG, the glycogen targeting subunit of the R5/PTGprotein phosphatase 1 holoenzyme, and accelerates its downregulation by the laforin-malin complex. JB i o lC h e m2009,
(2006). P: TRIP6 transcriptional co-activator is a novel substrate of AMP-activated protein kinase. Cell Signal
(2010). PJ: Genetic depletion of the malin E3 ubiquitin ligase in mice leads to lafora bodies and the accumulation of insoluble laforin.
(2005). ProtTest: selection of best-fit models of protein evolution. Bioinformatics
(2008). Rodriguez de Cordoba S: Regulation of glycogen synthesis by the laforinmalin complex is modulated by the AMP-activated protein kinase pathway. Human Mol Genet
(1998). Ruvkun G: A novel repeat domain that is often associated with RING finger and B-box motifs. Trends Biochem Sci
(2005). Saib A: TRIM family proteins: retroviral restriction and antiviral defence. Nat Rev Microbiol
(2005). SH: CDD: a Conserved Domain Database for protein classification. Nucleic Acids Res
(2000). Sudarsanam S: Visualizing large hierarchical clusters in hyperbolic space. Bioinformatics
(2009). SUPERFAMILY–sophisticated comparative genomics, data mining, visualization and phylogeny. Nucleic Acids Res
(1998). SW: Mutations in a gene encoding a novel protein tyrosine phosphatase cause progressive myoclonus epilepsy. Nature Genetics
(2003). SW: Mutations in NHLRC1 cause progressive myoclonus epilepsy. Nature Genetics
(2002). T: MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform. Nucleic Acids Res
(2005). Tagwerker C: Is this protein ubiquitinated? Methods Enzymol
(2006). The interaction of Piasy with Trim32, an E3-ubiquitin ligase mutated in limb-girdle muscular dystrophy type 2H, promotes Piasy degradation and regulates UVB-induced keratinocyte apoptosis through NFkappaB.
(2010). The laforin-malin complex, involved in Lafora disease, promotes the incorporation of K63-linked ubiquitin chains into AMP-activated protein kinase beta subunits. Mol Biol Cell
(2007). The SUPERFAMILY database in 2007: families and functions. Nucleic Acids Res
(2009). Worby CA: Lafora disease: insights into neurodegeneration from plant metabolism. Trends Biochem Sci