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Lafora disease E3-ubiquitin ligase malin is related to TRIM32 at both the phylogenetic and functional level

By Carlos Romá-Mateo, Daniel Moreno, Santiago Vernia, Teresa Rubio, Travis M Bridges, Matthew S Gentry and Pascual Sanz
Topics: Research Article
Publisher: BioMed Central
OAI identifier: oai:pubmedcentral.nih.gov:3160408
Provided by: PubMed Central

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  1. (2010). A: The Pfam protein families database. Nucleic Acids Res
  2. (2003). Aggarwal AK: Model of the brain tumor-Pumilio translation repressor complex. Genes Dev
  3. (2007). al: Ensembl 2007. Nucleic Acids Res
  4. (2004). Alber T: Sensor domain of the Mycobacterium tuberculosis receptor Ser/Thr protein kinase, PknD, forms a highly symmetric beta propeller.
  5. (2001). Ballabio A: The tripartite motif family identifies cell compartments.
  6. (2001). Chothia C: Assignment of homology to genome sequences using a library of hidden Markov models that represent all proteins of known structure.
  7. (2009). Ciechanover A: Targeting proteins for destruction by the ubiquitin system: implications for human pathobiology. Annu Rev Pharmacol Toxicol
  8. (2009). Conservation of the glucan phosphatase laforin is linked to rates of molecular evolution and the glucan metabolism of the organism.
  9. (2006). Cox TC: Subclassification of the RBCC/TRIM superfamily reveals a novel motif necessary for microtubule binding.
  10. (1999). de Cordoba SR: A novel protein tyrosine phosphatase gene is mutated in progressive myoclonus epilepsy of the Lafora type (EPM2). Human Mol Genet
  11. (2002). Depiereux E: ESyPred3D: Prediction of proteins 3D structures. Bioinformatics
  12. (2009). DJ: TRIM32 is an E3 ubiquitin ligase for dysbindin. Human Mol Genet
  13. (2008). Genomic analysis of the TRIM family reveals two groups of genes with distinct evolutionary properties.
  14. (2007). Guinovart JJ: Mechanism suppressing glycogen synthesis in neurons and its demise in progressive myoclonus epilepsy. Nat Neurosci
  15. (2008). HC: TRIM family proteins and their emerging roles in innate immunity. Nat Rev Immunol
  16. (2005). Insights into Lafora disease: malin is an E3 ubiquitin ligase that ubiquitinates and promotes the degradation of laforin. Proc Natl Acad Sci USA
  17. (2007). JE: The phosphatase laforin crosses evolutionary boundaries and links carbohydrate metabolism to neuronal disease.
  18. (2009). Joazeiro CA: RING domain E3 ubiquitin ligases. Annu Rev Biochem
  19. (2009). Knoblich JA: The TRIM-NHL protein TRIM32 activates microRNAs and prevents self-renewal in mouse neural progenitors. Cell
  20. (2009). Lafora progressive myoclonus epilepsy: a metaanalysis of reported mutations in the first decade following the discovery of the EPM2A and NHLRC1 genes. Hum Mutat
  21. (2008). Malin decreases glycogen accumulation by promoting the degradation of protein targeting to glycogen (PTG).
  22. (2005). MJ: Trim32 is a ubiquitin ligase mutated in limb girdle muscular dystrophy type 2H that binds to skeletal muscle myosin and ubiquitinates actin.
  23. (2008). Mutations that impair interaction properties of TRIM32 associated with limb-girdle muscular dystrophy 2H. Hum Mutat
  24. (2004). Only six kingdoms of life. Proc Biol Sci
  25. P: AMP-activated protein kinase phosphorylates R5/PTG, the glycogen targeting subunit of the R5/PTGprotein phosphatase 1 holoenzyme, and accelerates its downregulation by the laforin-malin complex. JB i o lC h e m2009,
  26. (2006). P: TRIP6 transcriptional co-activator is a novel substrate of AMP-activated protein kinase. Cell Signal
  27. (2010). PJ: Genetic depletion of the malin E3 ubiquitin ligase in mice leads to lafora bodies and the accumulation of insoluble laforin.
  28. (2005). ProtTest: selection of best-fit models of protein evolution. Bioinformatics
  29. (2008). Rodriguez de Cordoba S: Regulation of glycogen synthesis by the laforinmalin complex is modulated by the AMP-activated protein kinase pathway. Human Mol Genet
  30. (1998). Ruvkun G: A novel repeat domain that is often associated with RING finger and B-box motifs. Trends Biochem Sci
  31. (2005). Saib A: TRIM family proteins: retroviral restriction and antiviral defence. Nat Rev Microbiol
  32. (2005). SH: CDD: a Conserved Domain Database for protein classification. Nucleic Acids Res
  33. (2000). Sudarsanam S: Visualizing large hierarchical clusters in hyperbolic space. Bioinformatics
  34. (2009). SUPERFAMILY–sophisticated comparative genomics, data mining, visualization and phylogeny. Nucleic Acids Res
  35. (1998). SW: Mutations in a gene encoding a novel protein tyrosine phosphatase cause progressive myoclonus epilepsy. Nature Genetics
  36. (2003). SW: Mutations in NHLRC1 cause progressive myoclonus epilepsy. Nature Genetics
  37. (2002). T: MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform. Nucleic Acids Res
  38. (2005). Tagwerker C: Is this protein ubiquitinated? Methods Enzymol
  39. (2006). The interaction of Piasy with Trim32, an E3-ubiquitin ligase mutated in limb-girdle muscular dystrophy type 2H, promotes Piasy degradation and regulates UVB-induced keratinocyte apoptosis through NFkappaB.
  40. (2010). The laforin-malin complex, involved in Lafora disease, promotes the incorporation of K63-linked ubiquitin chains into AMP-activated protein kinase beta subunits. Mol Biol Cell
  41. (2007). The SUPERFAMILY database in 2007: families and functions. Nucleic Acids Res
  42. (2009). Worby CA: Lafora disease: insights into neurodegeneration from plant metabolism. Trends Biochem Sci