Article thumbnail

Construction of a computable cell proliferation network focused on non-diseased lung cells

By Jurjen W Westra, Walter K Schlage, Brian P Frushour, Stephan Gebel, Natalie L Catlett, Wanjiang Han, Sean F Eddy, Arnd Hengstermann, Andrea L Matthews, Carole Mathis, Rosemarie B Lichtner, Carine Poussin, Marja Talikka, Emilija Veljkovic, Aaron A Van Hooser, Benjamin Wong, Michael J Maria, Manuel C Peitsch, Renee Deehan and Julia Hoeng
Topics: Methodology Article
Publisher: BioMed Central
OAI identifier:
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles


  1. (2001). Acarregui MJ: VEGF induces airway epithelial cell proliferation in human fetal lung in vitro.
  2. (1996). AD: New insights into lung growth and development. Curr Opin Pediatr
  3. (2008). Adcock IM: Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction. Eur Respir J
  4. (2004). Almasan A: Opposing roles of E2Fs in cell proliferation and death. Cancer Biol Ther
  5. (1997). An alternative pathway for gene regulation by Myc. Embo J
  6. (1998). AP: Sonic hedgehog regulates branching morphogenesis in the mammalian lung. Curr Biol
  7. (2004). AW: Molecular signature of oncogenic rasinduced senescence. Oncogene
  8. (1994). B: NIH/3T3 cells transformed with the activated erbB-2 oncogene can be phenotypically reverted by a kinase deficient, dominant negative erbB-2 variant. Mol Cell Endocrinol
  9. (2003). Bioconductor: Open software development for computational biology and bioinformatics.
  10. (2005). Bioinformatics and computational biology solutions using R and Bioconductor. Statistics for Biology and Health
  11. (1997). BL: Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung. Development
  12. (2005). BL: Nmyc plays an essential role during lung development as a dosage-sensitive regulator of progenitor cell proliferation and differentiation. Development
  13. (2007). BN: Dendritic cells in asthma and COPD: opportunities for drug development. Curr Opin Immunol
  14. (2007). Bustelo XR: Transcriptomal profiling of the cellular transformation induced by Rho subfamily GTPases. Oncogene
  15. (2010). Causal reasoning identifies mechanisms of sensitivity for a novel AKT kinase inhibitor, GSK690693. BMC Genomics
  16. (2007). Cellular senescence in cancer and aging. Cell
  17. (2007). Cole TJ: Identification of glucocorticoid-regulated genes that control cell proliferation during murine respiratory development.
  18. (2007). Core Team: R: A Language and Environment for Statistical Computing. Book R: A Language and Environment for Statistical Computing (Editor eds.). City
  19. (1995). Derynck R: Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Nature
  20. (2006). DNA damage and tumor surveillance: one trigger for two pathways. Sci STKE
  21. (2009). Dutta A: p21 in cancer: intricate networks and multiple activities. Nat Rev Cancer
  22. (2009). Emerging roles of E2Fs in cancer: an exit from cell cycle control. Nat Rev Cancer
  23. (1992). Epidermal growth factor transcription, translation, and signal transduction by rat type II pneumocytes in culture.
  24. (1995). et al: Keratinocyte growth factor. Cell Biol Int
  25. (2005). Faehling M: Different effects of growth factors on proliferation and matrix production of normal and fibrotic human lung fibroblasts. Lung
  26. (2006). Forteza RM: Epidermal growth factor receptor activation by epidermal growth factor mediates oxidantinduced goblet cell metaplasia in human airway epithelium.
  27. (1997). Hann SR: Overexpression of c-Myc and cell immortalization alters c-Myc phosphorylation. Oncogene
  28. (2004). Hogan BL: Hyperactive Wnt signaling changes the developmental potential of embryonic lung endoderm.
  29. (1997). Hogan BL: Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis. Development
  30. (2008). Intrinsic sensor of oncogenic transformation induces a signal for innate immunosurveillance. Proc Natl Acad Sci USA
  31. (1994). JG: Expression of transforming growth factor-alpha and epidermal growth factor receptor is increased following bleomycin-induced lung injury in rats.
  32. (1997). JS: FGF-1 and FGF-7 induce distinct patterns of growth and differentiation in embryonic lung epithelium. Dev Dyn
  33. (2010). KEGG for representation and analysis of molecular networks involving diseases and drugs. Nucleic Acids Res
  34. (2004). Kowalik TF: Life, death and E2F: linking proliferation control and DNA damage signaling via E2F1. Cell Cycle
  35. (1998). Littlewood T: A matter of life and cell death. Science
  36. (2009). Loureiro JJ: SIRT1 promotes differentiation of normal human keratinocytes.
  37. (2004). MF: RAS and RHO GTPases in G1-phase cell-cycle regulation. Nat Rev Mol Cell Biol
  38. (2003). Miz1 is required for early embryonic development during gastrulation. Mol Cell Biol
  39. (1996). Morphogenesis of the lung: control of embryonic and fetal branching. Annu Rev Physiol
  40. (2007). Mosenifar Z: Differentiating COPD from asthma in clinical practice.
  41. (2010). MP: The role of hypoxia in 2-butoxyethanol-induced hemangiosarcoma. Toxicol Sci
  42. (1999). Prendergast GC: New Myc-interacting proteins: a second Myc network emerges. Oncogene
  43. (2001). RB: Adhesion-regulated G1 cell cycle arrest in epithelial cells requires the downregulation of c-Myc. Oncogene
  44. (2008). RJ: eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy.
  45. (2004). RJ: Keratinocyte growth factor stimulates alveolar type II cell proliferation through the extracellular signal-regulated kinase and phosphatidylinositol 3-OH kinase pathways.
  46. (2010). Selventa: Reverse Causal Reasoning Methods Whitepaper. [White paper]
  47. (1995). Sladek TL: Overexpression of the E2F-1 transcription factor gene mediates cell transformation. Gene Expr
  48. (2006). The retinoblastoma tumor-suppressor gene, the exception that proves the rule. Oncogene
  49. (2003). The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models. Bioinformatics
  50. (1988). Transmembrane signalling at epidermal growth factor receptors overexpressed in NIH 3T3 cells. Phosphoinositide hydrolysis, cytosolic Ca2+ increase and alkalinization correlate with epidermal-growth-factor-induced cell proliferation.
  51. (2010). Waters CM: Epithelial repair mechanisms in the lung.
  52. (2000). Weinberg RA: The hallmarks of cancer. Cell
  53. (1994). Whitsett JA: Respiratory epithelial cell expression of human transforming growth factor-alpha induces lung fibrosis in transgenic mice.
  54. (2009). WV: Notch signaling controls the balance of ciliated and secretory cell fates in developing airways. Development
  55. (2007). Zheng Y: Cell type-specific functions of Rho GTPases revealed by gene targeting in mice. Trends Cell Biol