Article thumbnail

Succinate Dehydrogenase Is a Direct Target of Sirtuin 3 Deacetylase Activity

By Lydia W. S. Finley, Wilhelm Haas, Valérie Desquiret-Dumas, Douglas C. Wallace, Vincent Procaccio, Steven P. Gygi and Marcia C. Haigis
Topics: Research Article
Publisher: Public Library of Science
OAI identifier: oai:pubmedcentral.nih.gov:3157345
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles

Citations

  1. (2008). A mitochondrial protein compendium elucidates complex I disease biology.
  2. (2008). A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis.
  3. (2010). A tissue-specific atlas of mouse protein phosphorylation and expression.
  4. (2009). Calorie restriction alters mitochondrial protein acetylation.
  5. (2010). Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation.
  6. (1999). Controlling caloric consumption: protocols for rodents and rhesus monkeys.
  7. (2005). Crystal structure of mitochondrial respiratory membrane protein complex II.
  8. (2006). Crystallographic studies of the binding of ligands to the dicarboxylate site of Complex II, and the identity of the ligand in the ‘‘oxaloacetate-inhibited’’ state.
  9. (2005). Extension of murine life span by overexpression of catalase targeted to mitochondria.
  10. (2003). Function and structure of complex II of the respiratory chain.
  11. (2009). Lysine acetylation targets protein complexes and co-regulates major cellular functions.
  12. (2007). Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.
  13. (1995). Mutation of a nuclear succinate dehydrogenase gene results in mitochondrial respiratory chain deficiency.
  14. (2006). Optimization and use of peptide mass measurement accuracy in shotgun proteomics.
  15. (2000). Progress in understanding structure-function relationships in respiratory chain complex II.
  16. (2009). Recent progress in the biology and physiology of sirtuins.
  17. (2010). Regulation of cellular metabolism by protein lysine acetylation.
  18. (2011). Regulation of intermediary metabolism by protein acetylation.
  19. (2010). Regulation of succinate dehydrogenase activity by SIRT3 in mammalian mitochondria.
  20. (2010). Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy. Aging
  21. (2006). Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2.
  22. (2009). Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice.
  23. (2010). SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production.
  24. (2010). SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress.
  25. (2010). Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction.
  26. (2011). SIRT3 opposes reprogramming of cancer cell metabolism through HIF1alpha destabilization.
  27. (2011). Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction.
  28. (2010). SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation.
  29. (2010). Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress.
  30. (2005). SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes.
  31. (2006). SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells.
  32. (2010). Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling.
  33. (2006). Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases.
  34. (2003). Stop and go extraction tips for matrix-assisted laser desorption/ionization, nanoelectrospray, and LC/MS sample pretreatment in proteomics.
  35. (2006). Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.
  36. (2008). Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5.
  37. (2007). Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry.
  38. (2003). The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase.
  39. (2011). the Thermogenic Brown Adipocyte Phenotype.
  40. (2004). UCSF Chimera–a visualization system for exploratory research and analysis.