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Principal role of adenylyl cyclase 6 in K+ channel regulation and vasodilator signalling in vascular smooth muscle cells

By Carl P. Nelson, Richard D. Rainbow, Jennifer L. Brignell, Matthew D. Perry, Jonathon M. Willets, Noel W. Davies, Nicholas B. Standen and R.A. John Challiss
Topics: Original Articles
Publisher: Oxford University Press
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Provided by: PubMed Central

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  7. (1993). Arteriolar tone is determined by activity of ATP-sensitive potassium channels.
  8. (1997). ATP-sensitive and inwardly rectifying potassium channels in smooth muscle. Physiol Rev
  9. (1998). ATP-sensitive K + channel activation by calcitonin gene-related peptide and protein kinase A in pig coronary arterial smooth muscle.
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  11. (2009). Capturing adenylyl cyclases as potential drug targets. Nat Rev Drug Discov
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  13. Challiss RAJ et al.G protein-coupled receptor kinase 2 and arrestin2 regulate arterial smooth muscle P2Y-purinoceptor signalling.
  14. (2002). Controlled expression of cardiac-directed adenylylcyclase type VI provides increased contractile function. Cardiovasc Res
  15. (2006). Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific therapeutic agents. Pharmacol Ther
  16. (2004). Diabetes-related changes in cAMP-dependent protein kinase activity and decrease in relaxation response in rat mesenteric artery.
  17. Disruption of type 5 adenylyl cyclase gene preserves cardiac function against pressure overload.
  18. Episodic coronary artery vasospasm and hypertension develop in the absence of Sur2 KATP channels.
  19. (1995). Forearm b-adrenergic receptor-mediated vasodilation is impaired, without alteration of forearm norepinephrine spillover, in borderline hypertension.
  20. Gq-mediated Ca 2+ signals inhibit adenylyl cyclases 5/6 in vascular smooth muscle cells.
  21. Increased enzyme activity and b-adrenergic mediated vasodilation in subjects expressing a single-nucleotide variant of human adenylyl cyclase 6. Arterioscler Thromb Vasc Biol 2007;27:2657–2663.
  22. Interaction with caveolin-1 modulates vascular ATP-sensitive potassium (KATP) channel activity.
  23. (1993). Ionic currents in rat pulmonary and mesenteric arterial myocytes in primary culture and subculture.
  24. (1995). Isoproterenol causes hyperpolarization through opening of ATP-sensitive potassium channels in vascular smooth muscle of the canine saphenous vein.
  25. Localization of adenylyl cyclase isoforms and G protein-coupled receptors in vascular smooth muscle cells: expression in caveolin-rich and noncaveolin domains.
  26. Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1.
  27. (2007). New signalling pathways associated with increased cardiac adenylyl cyclase 6 expression: implications for possible congestive heart failure therapy. Trends Cardiovasc Med
  28. (2007). Organization and Ca 2+ regulation of adenylyl cyclases in cAMP microdomains. Physiol Rev
  29. (1995). Physiological roles and properties of potassium channels in arterial smooth muscle.
  30. (2000). Polymorphisms of the b2-adrenergic receptor determine exercise capacity in patients with heart failure. Circ Res
  31. (1993). Role of K + ATP channels in coronary vasodilation during exercise. Circulation
  32. (2006). Spontaneous coronary vasospasm in KATP mutant mice arises from a smooth muscle-extrinsic process. Circ Res
  33. Stimulation of forskolin of intact S49 lymphoma cells involves the nucleotide regulatory protein of adenylate cyclase.
  34. Subcellular dynamics of protein kinase A activity visualized by FRET-based reporters.
  35. (2000). Sympathetic control of arterial membrane potential by ATP-sensitive K +-channels. Hypertension
  36. (1988). Targeted disruption of the b2-adrenergic receptor gene. J Biol Chem 1999;274:16694–16700. Role of AC6 in aortic smooth muscle cells 70110. Asano
  37. (1998). The Ile164 b2-adrenergic receptor polymorphism adversely affects the outcome of congestive heart failure.
  38. (1995). The involvement of ATP-sensitive potassium channels in b-adrenoceptor-mediated vasorelaxation in the rat isolated mesenteric arterial bed.