Article thumbnail

Peroxisome proliferator activator receptor gamma coactivator-1alpha (PGC-1α) improves motor performance and survival in a mouse model of amyotrophic lateral sclerosis

By Wei Zhao, Merina Varghese, Shrishailam Yemul, Yong Pan, Alice Cheng, Paul Marano, Sadiq Hassan, Prashant Vempati, Fei Chen, Xianjuan Qian and Giulio M Pasinetti
Topics: Research Article
Publisher: BioMed Central
OAI identifier: oai:pubmedcentral.nih.gov:3156746
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles

Citations

  1. (2002). A quantitative histochemical assay for activities of mitochondrial electron transport chain complexes in mouse spinal cord sections.
  2. (1998). Beal MF: Metabolic dysfunction in familial, but not sporadic, amyotrophic lateral sclerosis.
  3. (1993). Beal MF: Superoxide dismutase activity, oxidative damage, and mitochondrial energy metabolism in familial and sporadic amyotrophic lateral sclerosis.
  4. (2003). Bendotti C: Persistent activation of p38 mitogen-activated protein kinase in a mouse model of familial amyotrophic lateral sclerosis correlates with disease progression. Mol Cell Neurosci
  5. (2005). BM: Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle. Cell Metab
  6. CC: p38alpha stress-activated protein kinase phosphorylates neurofilaments and is associated with neurofilament pathology in amyotrophic lateral sclerosis. M o lC e l lN e u r o s c i2004,
  7. (2010). CR: PGC-1alpha, a potential therapeutic target for early intervention in Parkinson’s disease. Sci Transl Med
  8. (1990). Cresyl violet: a red fluorescent Nissl stain.
  9. (1994). Deng HX: Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation. Science
  10. (1993). Deng HX: Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature
  11. (1999). Direct proteasome inhibition by clasto-lactacystin beta-lactone permits the detection of ubiquitinated p21(waf1) in ML-1 cells. Biochim Biophys Acta
  12. (1999). DW: Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neurons. Nat Neurosci
  13. (2004). DW: Unraveling the mechanisms involved in motor neuron degeneration in ALS. Annu Rev Neurosci
  14. (1998). Hantraye P: Partial inhibition of brain succinate dehydrogenase by 3-nitropropionic acid is sufficient to initiate striatal degeneration in rat.
  15. (2005). Heneka MT: The oral antidiabetic pioglitazone protects from neurodegeneration and amyotrophic lateral sclerosis-like symptoms in superoxide dismutase-G93A transgenic mice.
  16. (2009). Holzbaur EL: A switch in retrograde signaling from survival to stress in rapid-onset neurodegeneration.
  17. (2010). Impaired glucose tolerance in patients with amyotrophic lateral sclerosis. Amyotroph Lateral Scler
  18. (1998). Jr: Mitochondria in sporadic amyotrophic lateral sclerosis. Exp Neurol
  19. (2006). Krainc D: Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration. Cell
  20. (2005). Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab
  21. (2009). MF: Impaired PGC-1alpha function in muscle in Huntington’s disease. Hum Mol Genet
  22. (1999). MF: Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis. Nat Med
  23. (2005). MF: Peroxisome proliferatoractivated receptor-gamma agonist extends survival in transgenic mouse model of amyotrophic lateral sclerosis. Exp Neurol
  24. (2000). Mitochondria and the pathogenesis of ALS.
  25. (2005). Mitochondrial dysfunction and its role in motor neuron degeneration in ALS. Mitochondrion
  26. (2002). Mitochondrial electron transport chain complex dysfunction in a transgenic mouse model for amyotrophic lateral sclerosis.
  27. (2008). Mitochondrial NAD+-linked State 3 respiration and complex-I activity are compromised in the cerebral cortex of 3-nitropropionic acid-induced rat model of Huntington’s disease.
  28. (2002). Mutated human SOD1 causes dysfunction of oxidative phosphorylation in mitochondria of transgenic mice.
  29. (2006). Pasinetti GM: Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction.
  30. (2009). Pasinetti GM: PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia. Arch Neurol
  31. (1999). Pasinetti GM: Potentiation of excitotoxicity in transgenic mice overexpressing neuronal cyclooxygenase-2. Am J Pathol
  32. (2006). RH: Molecular biology of amyotrophic lateral sclerosis: insights from genetics. Nat Rev Neurosci
  33. (2006). ST: JNK mediates pathogenic effects of polyglutamine-expanded androgen receptor on fast axonal transport. Nat Neurosci
  34. (2000). Tumor necrosis factor induces hyperphosphorylation of kinesin light chain and inhibits kinesin-mediated transport of mitochondria.