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Sex Chromosome-Specific Regulation in the Drosophila Male Germline But Little Evidence for Chromosomal Dosage Compensation or Meiotic Inactivation

By Colin D. Meiklejohn, Emily L. Landeen, Jodi M. Cook, Sarah B. Kingan and Daven C. Presgraves


Suppression of X-linked transgene reporters versus normal expression of endogenous X-linked genes suggest a novel form of X chromosome-specific regulation in Drosophila testes, instead of sex chromosome dosage compensation or meiotic inactivation

Topics: Research Article
Publisher: Public Library of Science
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Provided by: PubMed Central

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  1. (2008). A bird’s-eye view of sex chromosome dosage compensation.
  2. (2006). A dynamic view of sex chromosome evolution.
  3. (2008). A mouse speciation gene encodes a meiotic histone H3 methyltransferase.
  4. (1998). A rapidly evolving homeobox at the site of a hybrid sterility gene.
  5. (2007). A sex-ratio meiotic drive system in Drosophila simulans. II: an X-linked distorter.
  6. (2008). A single gene causes both male sterility and segregation distortion in Drosophila hybrids.
  7. (2009). Altered heterochromatin binding by a hybrid sterility protein in Drosophila sibling species.
  8. (2009). Alternative splicing of NURF301 generates distinct NURF chromatin remodeling complexes with altered modified histone binding specificities.
  9. (1998). An analysis of maleless and histone H4 acetylation in Drosophila melanogaster spermatogenesis.
  10. (1997). bag-of-marbles and benign gonial cell neoplasm act in the germline to restrict proliferation during Drosophila spermatogenesis.
  11. (2003). Battle of the Xs.
  12. Buffering and the evolution of chromosome-wide gene regulation.
  13. (2009). Buffering segmental and chromosomal aneuploidies in Drosophila melanogaster.
  14. (1986). Chromatin organization in the male germ line of Drosophila hydei.
  15. (2005). Chromatin remodeling in dosage compensation.
  16. (1995). Controlling the false discovery rate: a practical and powerful approach to multiple testing.
  17. (2005). Cross-species comparison of Drosophila male accessory gland protein genes.
  18. (2007). Demasculinization of X chromosomes in the Drosophila genus.
  19. (2009). Dosage analysis of Z chromosome genes using microarray in silkworm, Bombyx mori.
  20. (2010). Dosage compensation and demasculinization of X chromosome in Drosophila.
  21. (2007). Dosage compensation goes global.
  22. (1973). Dosage compensation in Drosophila.
  23. (2008). Drive and sperm: evolution and genetics of male meiotic drive.
  24. (2009). Drosophila dosage compensation: a complex voyage to the X chromosome.
  25. (2010). Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq.
  26. (1950). Evidence of the precision of genetic adaptation.
  27. (1993). Evolution of postmating reproductive isolation: the composite nature of Haldane’s rule and its genetic bases.
  28. (1983). Evolution of sex determining mechanisms. Menlo ParkCA: Benjamin/Cummings Publishing Co.
  29. (1995). Expression of msl-2 causes assembly of dosage compensation regulators on the X chromosomes and female lethality in Drosophila.
  30. (1967). Extraordinary sex ratios.
  31. Fine-Scale Analysis of X chromosome inactivation in the male germ line of Drosophila melanogasterMolBiolEvol28:.
  32. (1961). Gene action in the X-chromosome of the mouse (Mus musculus L).
  33. (2009). Genetic conflict and sex chromosome evolution.
  34. (1998). Genetic control of cell proliferation and differentiation in Drosophila spermatogenesis.
  35. (2003). Genetic dissection of hybrid incompatibilities between Drosophila simulans
  36. (1992). Genetics and speciation.
  37. (2007). Genome-wide patterns of expression in Drosophila pure species and hybrid males. II. Examination of multiple-species hybridizations, platforms, and life cycle stages.
  38. (2006). Global analysis of X-chromosome dosage compensation.
  39. (2005). Global regulation of X chromosomal genes by the MSL complex in Drosophila melanogaster.
  40. (2007). High-resolution genome-wide dissection of the two rules of speciation in Drosophila.
  41. (1996). Hybrid sterility in the mouse.
  42. (2011). Lack of global meiotic sex chromosome inactivation, and paucity of tissue-specific gene expression on the Drosophila X chromosome.
  43. (2004). Linear models and empirical bayes methods for assessing differential expression in microarray experiments.
  44. (2002). Male-driven evolution. Curr Opin Genet Dev.
  45. (1980). Male-specific lethal mutations of Drosophila melanogaster.
  46. (2007). Meiotic sex chromosome inactivation.
  47. (2001). Molecular evolution of the ocnus and janus genes in the Drosophila melanogaster subgroup.
  48. (2010). Molecular mechanisms of gene regulation during Drosophila spermatogenesis.
  49. (1986). Mutations affecting dosage compensation in Drosophila melanogaster: effects in the germline.
  50. (1989). Patterns of speciation in Drosophila.
  51. (1997). Patterns of speciation in Drosophila’’ revisited.
  52. (2003). Paucity of genes on the Drosophila X chromosome showing male-biased expression.
  53. (2003). Pomiankowski A
  54. (2006). Postmeiotic sex chromatin in the male germline of mice.
  55. (2008). R: a language and environment for statistical computing. ViennaAustria: R Foundation for Statistical Computing.
  56. (1995). Regulation of beta-tubulin function and expression in Drosophila spermatogenesis.
  57. (2006). roX RNAs are required for increased expression of X-linked genes in Drosophila melanogaster males.
  58. (1995). Scha ¨fer U
  59. Schlotterer C Non-random genomic integration - an intrinsic property of retrogenes in Drosophila?
  60. (1993). Sex chromosomes, recombination, and chromatin conformation.
  61. (2005). Silencing of unsynapsed meiotic chromosomes in the mouse.
  62. (1997). Site-directed mutations reveal long-range compensatory interactions in the Adh gene of Drosophila melanogaster.
  63. (2009). Stage-specific expression profiling of Drosophila spermatogenesis suggests that meiotic sex chromosome inactivation drives genomic relocation of testis-expressed genes.
  64. (1974). The behaviour of the XY pair in mammals.
  65. (1995). The dosage compensation regulators MLE, MSL-1 and MSL-2 are interdependent since early embryogenesis in Drosophila.
  66. (2005). The Drosophila MSL complex activates the transcription of target genes.
  67. (2008). The mouse X chromosome is enriched for multicopy testis genes showing postmeiotic expression.
  68. (2009). The multicopy gene sly represses the sex chromosomes in the male mouse germline after meiosis.
  69. (1972). The role of the X-chromosome inactivation during spermatogenesis.
  70. (2009). TopHat: discovering splice junctions with RNA-Seq.
  71. (2011). Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation.
  72. (1989). Two rules of speciation.
  73. (1987). Use of P-element-mediated transformation to identify the molecular basis of naturally occurring variants affecting Adh expression in Drosophila melanogaster.
  74. (2007). Using FlyAtlas to identify better Drosophila melanogaster models of human disease.
  75. (2010). Widespread overexpression of the X chromosome in sterile F1 hybrid mice.
  76. X chromosome dosage compensation via enhanced transcriptional elongation in Drosophila.
  77. (2007). X chromosome inactivation during Drosophila spermatogenesis.
  78. (2007). X chromosome reactivation initiates in nascent primordial germ cells in mice.
  79. (1972). X-chromosome inactivation: an essential feature of normal spermiogenesis in male heterogametic organisms.
  80. (2009). XY and ZW: is meiotic sex chromosome inactivation the rule in evolution?