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Cytocompatibility of Medical Biomaterials Containing Nickel by Osteoblasts: a Systematic Literature Review

By Marcin Mikulewicz and Katarzyna Chojnacka

Abstract

The present review is based on a survey of 21 studies on the cytocompatibility of medical biomaterials containing nickel, as assessed by cell culture of human and animal osteoblasts or osteoblast-like cells. Among the biomaterials evaluated were stainless steel, NiTi alloys, pure Ni, Ti, and other pure metals. The materials were either commercially available, prepared by the authors, or implanted by various techniques to generate a protective layer of oxides, nitrides, acetylides. The observation that the layers significantly reduced the initial release of metal ions and increased cytocompatibility was confirmed in cell culture experiments. Physical and chemical characterization of the materials was performed. This included, e.g., surface characterization (roughness, wettability, corrosion behavior, quantity of released ions, microhardness, and characterization of passivation layer). Cytocompatibility tests of the materials were conducted in the cultures of human or animal osteoblasts and osteoblast-like cells. The following assays were carried out: cell proliferation and viability test, adhesion test, morphology (by fluorescent microscopy or SEM). Also phenotypic and genotypic markers were investigated. In the majority of works, it was found that the most cytocompatible materials were stainless steel and NiTi alloy. Pure Ni was rendered and less cytocompatible. All the papers confirmed that the consequence of the formation of protective layers was in significant increase of cytocompatibility of the materials. This indicates the possible further modifications of the manufacturing process (formation of the passivation layer)

Topics: Article
Publisher: Humana Press Inc
OAI identifier: oai:pubmedcentral.nih.gov:3152710
Provided by: PubMed Central

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Citations

  1. (1999). A new prosthesis for the metacarpophalangeal joint. Study of materials and biomechanics.
  2. (1995). Allergic reaction to nickel orthodonticwire: a casereport.Quintessence Int 26:385–387
  3. (1989). Allergic reaction to orthodontic wire: report of a case.
  4. (2000). Application of stripping voltammetry and microelectrodesin vitro biocompatibility and in vivo toxicity tests of AISI 316 L corrosion products.
  5. (1998). Assessing the biocompatibility of NiTi shape memory alloys used for medical applications.
  6. (1997). Biocompatibility of nickel– titanium shape memory metal and its corrosion behavior in human cell cultures.
  7. (1996). Biocompatibility testing of NiTi screws using immunohistochemistry on sections containing metallic implants.
  8. (2003). Biomaterials in orthopedic surgery: effects of a nickel-reduced stainless steel on in vitro proliferation and activation of human osteoblasts.
  9. (2001). Biomedical and dental materials: introduction. In: Buschow
  10. (1997). Carcinogenicity assessment of selected nickel compounds.
  11. (2010). Cellular activity of bioactive nanograined/ultrafine-grained materials.
  12. (2007). Cellular biomechanics, biomechanics—from cells to organisms.
  13. (1992). Cemented versus cementless hiparthroplasty. A review of prosthetic biocompatibility.
  14. (2007). Changed clinical chemistry pattern in blood after removal of dental amalgam and other metal alloys supported by antioxidant therapy.
  15. (2003). Cigada A
  16. (1983). Contact dermatitis reaction to a metal buckle on a cervical headgear.
  17. (2005). Corrosion resistance, surface mechanical properties, and cytocompatibility of plasma immersion ion implantation-treated nickel–titanium shape memory alloys.
  18. (1999). Corrosion, microbial. In: Flickinger MC, Drew SW (eds) Encyclopedia of bioprocess technology: fermentation, biocatalysis and bioseparation.
  19. (2007). Cytotoxicity of polyethyleneimine (PEI), precursor base layer of polyelectrolyte multilayer films.
  20. (2006). Decrease of trace elements in erythrocytes and plasma after removal of dental amalgam and other metal alloys.
  21. (2002). Easy assessment of the biocompatibility of Ni–Ti alloys by in vitro cell culture experiments on a functionally graded Ni–NiTi–Ti material.
  22. (2002). Effect of metal alloy surface stresses on the viability of ROS-17/2.8 osteoblastic cells.
  23. (2004). Engineering materials for biomedical applications. World Scientific,
  24. (2005). Enhanced human osteoblast cell adhesion and proliferation on 316 LS stainless steel by means of CO2 laser surface treatment.
  25. (2008). Evaluation of ion release, cytotoxicity, and platelet adhesion of electrochemical anodized 316 L stainless steel cardiovascular stents.
  26. (2005). Evaluation of mechanical properties and biological response of analumina-forming Ni-free ferritic alloy.
  27. (1996). Evaluation of the effect of three surface treatments on the biocompatibility of 316L stainless steel using human differentiated cells.
  28. (2003). Experimental systemic contact dermatitis from nickel: a dose response study.
  29. (2010). for Testing and Materials (ASTM) F136.
  30. (1998). Handbook of biomaterial properties.
  31. (1996). Hensten-Pettersen A
  32. (1998). In vitro biomineralization by osteoblast-like cells. I. Retardation of tissue mineralization by metal salts.
  33. (2002). Interaction of spiral ganglion neuron processes with alloplastic materials in vitro.
  34. (2005). Investigation of nickel suppression and cytocompatibility of surface-treated nickel–titanium shape memory alloys by using plasma immersion ion implantation.
  35. ISO 10993-5:2009 Biological evaluation of medical devices—Part 5: tests for in vitro cytotoxicity
  36. (2008). Mechanical properties and biocompatibility of plasma-nitrided laser-cut 316 L cardiovascular stents.
  37. (1996). Metal carcinogenesis in total joint arthroplasty. Animal models.
  38. (1998). Metallic biomaterials. In: Black J, Hastings G (eds) Handbook of biomaterial properties.
  39. (2004). Metallic dental material biocompatibility in osteoblast like cells: correlation with metal ion release.
  40. (2009). Microarraybased gene expression analysis of human osteoblasts in response to different biomaterials.
  41. (2009). Nano-scale surface morphology, wettability and osteoblast adhesion on nitrogen plasmaimplanted NiTi shape memory alloy.
  42. (1993). Nickel hypersensitivity in the orthodontic patient.
  43. (1998). Nickel hypersensitivity reaction before, during, and after orthodontic therapy.
  44. (2006). Nickel in dental plaque and saliva in patients with and without orthodontic appliances.
  45. (2007). Nickel release behavior, cytocompatibility, and superelasticity of oxidized porous singlephase NiTi.
  46. (1993). Nickel, cobalt and chromium in consumer products: a role in allergenic contact dermatitis? Contact Dermat
  47. (2001). Nitinol as a biomedical material. In: Buschow
  48. (1994). Oliva A
  49. (2001). Osteoblast cell death on methacrylate polymers involves apoptosis.
  50. (2008). Osteoblast responses to different oxide coatings produced by the sol–gel process on titanium substrates.
  51. (2008). Oxidized NiTi surfaces enhance differentiation of osteoblast-like cells.
  52. (2008). Prevalence of nickel hypersensitivity in orthodontic patients: a meta-analysis.
  53. (2001). Proliferation and differentiation parameters of human osteoblasts on titanium and steel surfaces.
  54. (2006). Promising in vitro performances of a new nickel-free stainless steel.
  55. (2002). Rapid analysis of biocompatibility with graded test samples exemplified by Ni–NiTi–Ti.
  56. (2010). Release of metal ions from orthodontic appliances by in vitro studies: a systematic literature review. Biol Trace Elem Res.
  57. (2002). Silver coated materials for external fixation devices: in vitro biocompatibility and genotoxicity.
  58. (2005). Soft tissue response to a new austenitic stainless steel with a negligible nickel content.
  59. (2007). Spark plasma sintering synthesis of porous nanocrystalline titanium alloys for biomedical applications.
  60. (1994). Stomatitis or systemically-induced contactdermatitis.
  61. (2008). Study of salivary strontium and silver concentrations in primary school children related to dental caries.
  62. (2007). Surface characteristics, biocompatibility, and mechanical properties of nickel–titanium plasmaimplanted with nitrogen at different implantation voltages.
  63. (2006). Surface characteristics, mechanical properties, and cytocompatibility of oxygen plasmaimplanted porous nickel titanium shape memory alloy.
  64. (2007). Surface mechanical properties, corrosion resistance, and cytocompatibility of nitrogen plasmaimplanted nickel-titanium alloys: a comparative study with commonly used medical grade materials.
  65. (1997). The carcinogenicity of metals in humans.
  66. (2009). The positive influence of electrochemical cyclic potentiodynamic passivation (CPP) of a SS316LS surface on its response to fibronectin and preosteoblasts.
  67. (1997). The response of primary rat and human osteoblasts and an immortalized rat osteoblast cell line to orthopaedic materials: comparative sensitivity of several toxicity indices.
  68. (2006). The study on biocompatibility of diamond-like carbon coated nickel– titanium shape memory alloy with osteoblasts cultured in vitro. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
  69. (2009). Tooth element levels indicating exposure profiles in diabetic and hypertensive subjects from Mysore, India. Biol Trace Elem Res 131:255–262 Cytocompatibility of Biomaterials Containing Nickel by Osteoblast 889
  70. (1994). Toxic effects caused by stainless steel corrosion products on mouse seminiferous cells. Cytobios 77:73–80
  71. (2010). Trace metal release from orthodontic appliances by in vivo studies: a systematic literature review. Biol Trace Elem Res.