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Metastatic collecting duct carcinoma of the kidney treated with sunitinib

By El Mehdi Tazi, Ismail Essadi, Mohamed Fadl Tazi, Youness Ahellal, Hind M'rabti and Hassan Errihani


Collecting duct carcinoma (CDC) of the kidney is a rare and aggressive malignant tumor arising from the distal collecting tubules which has been shown to have a poor response to several kinds of systemic therapy. We present a case of metastatic CDC that responded favorably to a multiple tyrosine kinase inhibitor, sunitinib, achieving a partial response in both lung and skeletal metastases. To our knowledge, this is the first report showing therapeutic activity of sunitinib against CDC. Considering these findings, it would be worthwhile prospectively investigating the role of multiple tyrosine kinase inhibitors, particularly sunitinib, in the management of metastatic CDC

Topics: Case Report
Publisher: BioMed Central
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Provided by: PubMed Central

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  1. (2001). Atkins MB: Long-term remission in a patient with metastatic collecting duct carcinoma treated with taxol/ carboplatin and surgery. Urology
  2. (2008). Clinical effect and future considerations for molecularly-targeted therapy in renal cell carcinoma. Urol Oncol
  3. (2007). Culine S: Prospective multicenter phase II study of gemcitabine plus platinum salt for metastatic collecting duct carcinoma: results of a GETUG (Groupe d’Etudes des Tumeurs UroGénitales) study.
  4. (1998). Eble JN: Collecting duct carcinoma of kidney. Semin Diagn Pathol
  5. (2008). Escudier B: Efficacy of sunitinib and sorafenib in metastatic papillary and chromophobe renal cell carcinoma.
  6. (2006). Igarashi T: Collecting duct (Bellini duct) renal cell carcinoma: a nationwide survey in Japan.
  7. (2002). Nanus DM: Active chemotherapy for collecting duct carcinoma of the kidney: a case report and review of the literature. Cancer
  8. (2003). Oudard S: Collecting duct carcinoma of the kidney: a clinicopathological study of 9 cases.
  9. (2002). Pantuck AJ: Collecting duct renal cell carcinoma: clinical study of a rare tumor.
  10. (2009). Sorafenib induces therapeutic response in a patient with metastatic collecting duct carcinoma of kidney. Onkologie