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The Serotonin Transporter Polymorphism (5-HTTLPR) and Alcohol Problems in Heavy Drinkers: Moderation by Depressive Symptoms

By Molly A. Tartter and Lara A. Ray

Abstract

Heavy alcohol use in young adults has been prospectively associated with a host of psychosocial and alcohol-related problems. Recent studies have supported the interaction between serotonin transporter polymorphism and adverse environmental factors, as a predictor of alcohol use and the development of alcohol dependence. The current study examined the role of depressive symptoms in combination with the serotonin transporter polymorphism as a predictor of alcohol use and alcohol-related problems. Results revealed a significant genotype by depressive symptom interaction, such that heavier alcohol use was associated with depressive symptoms in L allele homozygotes but not among S allele carriers. These results remained significant after controlling for ethnicity and gender effects. These findings extend the emerging literature supporting 5-HTTLPR genotype as a risk factor for alcohol-related problems in the context of co-occurring symptoms of depression

Topics: Psychiatry
Publisher: Frontiers Research Foundation
OAI identifier: oai:pubmedcentral.nih.gov:3151606
Provided by: PubMed Central

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Citations

  1. (2000). A relationship between serotonin transporter genotype and in vivo protein expression and alcohol neurotoxicity.
  2. (2008). A serotonin transporter gene polymorphism (5-HTTLPR), drinkingto-copemotivation,andnegativelife events among college students.
  3. (1994). A twin-family study of alcoholism in women.
  4. (2006). An evaluation of the level of response to alcohol, externalizingsymptoms,anddepressivesymptoms as predictors of alcoholism.
  5. (2005). An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk.
  6. (2009). An overview of genetic influences in alcoholism.
  7. and Kendler,K.S.(1999).Sexdifferences in the sources of genetic liability to alcohol abuse and dependence in a population-based sample of U.S.
  8. (2005). Association between 5-HTTLPR genotypes and persisting patterns of anxiety and alcohol use: results from a 10-year longitudinal study of adolescent mental health.
  9. (2007). Association of the long allele of the 5-HTTLPR polymorphism with compulsive craving in alcohol dependence.
  10. (2005). Association of the serotonin transporter gene polymorphism with Korean male alcoholics.
  11. (2009). Bingedrinkinginyoungadults:data, definitions, and determinants.
  12. (2008). Early-onset depressive disorders predict the use of addictive substances in adolescence: a prospective study of adolescentFinnishtwins.Addiction 103,
  13. (2011). Effects of the serotonin transporter (5-HTTLPR) and alpha2Aadrenoceptor (C-1291G) genotypes on substance use in children and adolescents: a longitudinal study.
  14. (2010). Genetic sensitivity to the environment:thecaseoftheserotonintransporter gene and its implications for studyingcomplexdiseasesandtraits.
  15. H.,andKranzler,H.R.(2007).Interactive effects of the serotonin transporter 5-HTTLPR polymorphism and stressful life events on college student drinking and drug use.
  16. (2009). Impact of age at first drink on vulnerability to alcoholrelated problems: testing the marker hypothesis in a prospective study of young adults.
  17. (2004). Impact of psychiatric comorbidity on treatment of adolescent drug abusers.
  18. (2009). Impact of psychosocial adversity on alcohol intake in young adults: moderation by the LL genotype of the serotonin transporter polymorphism.
  19. (2011). Influence of life stress on depression: moderation by a polymorphism in the 5-HTT Gene.
  20. (2004). Interactionbetweenserotonintransporter gene variation and rearing condition in alcohol preference and consumption in female primates.
  21. (2006). Low level of response to alcohol as associated with serotonin transporter genotype and high alcohol intake in adolescents.
  22. (2005). Meta-analysis of the association of a functional serotonin transporter promoter polymorphismwithalcoholdependence.
  23. (1998). On the validity of the Beck depression inventory.Areview.Psychopathology 31,
  24. (2009). Parenting moderates a genetic vulnerabilityfactorinlongitudinalincreases in youths’ substance use.
  25. (2004). Pharmacogenetic insights to monoaminergicdysfunctioninalcohol dependence.
  26. (2007). Prevalence, correlates, disability, and comorbidity of DSM-IV alcohol abuse and dependence in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions.
  27. (2004). Role of the serotonergic system in the neurobiology ofalcoholism:implicationsfortreatment.
  28. (2000). Serotonergic agents and alcoholism treatment: r e b i r t ho ft h es u b t y p ec o n c e p t–a n hypothesis.
  29. (2010). Stress-induced, and cue-induced craving for alcohol in heavy drinkers: preliminary evidence of genetic moderation by the OPRM1 and CRH-BP genes.
  30. (2000). The comorbidity of depression and substance use disorders.
  31. (2007). The factor structure of a dichotomously scored Rutgers Alcohol Problem Index.
  32. (1997). The human serotonin transporter gene polymorphism – basic research and clinical implications.
  33. (2008). The relationshipof5HTT(SLC6A4)methylation and genotype on mRNA expression andliabilitytomajordepressionand alcoholdependenceinsubjectsfrom the Iowa Adoption Studies.
  34. (1999). The role of neurocognitive abilities in coping with adolescent relapse to alcohol and drug use.
  35. (2010). The serotonin transporter gene and risk for alcohol dependence: a meta-analytic review. Drug Alcohol Depend.
  36. (2006). The temporal relationship of the onsets of alcohol dependence and major depression:usingageneticallyinformative study design.
  37. (1989). Towards the assessment of adolescent problem drinking.
  38. (2000). Updating Estimates of the Economic costs of Alcohol Abuse in the United States: Estimates, Update Methods, and Data. Rockville,MD:NationalInstituteon Alcohol Abuse and Alcoholism.
  39. Using the Timeline Followback to determine time windows representative of annual alcohol consumption with problem drinkers.
  40. What you need to know: detecting alcohol problems in general medical practice.SingaporeMed.J.39,38–41.