Article thumbnail

Highly pathogenic avian influenza H5N1 virus could partly be evacuated by pregnant BALB/c mouse during abortion or preterm delivery

By Lili Xu, Linlin Bao, Wei Deng and Chuan Qin


The highly pathogenic avian influenza H5N1 virus is one of candidates for future pandemic. Since H5N1 viruses had previously been isolated only from avian species, the outbreak raised questions about the ability of these viruses to cause severe disease and death in humans. Pregnant women are at increased risk for influenza-associated illness and death. However, little is known about whether influenza viruses could transmit to the fetus through the placenta, and the effects of abortion and preterm delivery to maternal influenza infection are not well understood. We found that the H5N1 viruses could vertical transmit to the fetus through the placenta in the BALB/c mouse model, and the viruses could partly be evacuated by the pregnant mice during abortion or preterm delivery. This study may further our understanding about the transmission of this highly pathogenic avian influenza viruses, supply optimized clinical treatment method for pregnant women, and shed some light on better preventing and controlling for future potential outbreak of H5N1 influenza pandemic

Topics: Short Report
Publisher: BioMed Central
OAI identifier:
Provided by: PubMed Central

Suggested articles


  1. (1959). Barno A: Deaths from Asian influenza associated with pregnancy.
  2. (1998). Cheng AF: Clinical features and rapid viral diagnosis of human disease associated with avian influenza A H5N1 virus. Lancet
  3. (1998). Cox N: Characterization of an avian influenza A (H5N1) virus isolated from a child with a fatal respiratory illness. Science
  4. (2005). DE: Pneumonia in pregnancy. Crit Care Med
  5. (2006). Emerging infections and pregnancy. Emerg Infect Dis
  6. (1919). Influenza occurring in pregnant women.
  7. Lethal avian influenza A (H5N1) infection in a pregnant woman in Anhui Province,
  8. (1998). MR: Impact of influenza on acute cardiopulmonary hospitalizations in pregnant women.
  9. (1918). pandemic influenza and pneumonia in a large civil hospital.
  10. (2007). Poon LL: Biology of influenza a virus.
  11. (1998). RG: Characterization of avian H5N1 influenza viruses from poultry in Hong Kong. Virology
  12. (1998). RG: Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus. Lancet
  13. (1957). Weisl BA: Maternal mortality in the epidemic of Asian influenza,
  14. (1997). WL: A pandemic warning? Nature
  15. (2008). Yang W: Clinical characteristics of 26 human cases of highly pathogenic avian influenza A (H5N1) virus infection in China. PLoS One

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.