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Lichenicidin Biosynthesis in Escherichia coli: licFGEHI Immunity Genes Are Not Essential for Lantibiotic Production or Self-Protection ▿

By Tânia Caetano, Joanna M. Krawczyk, Eva Mösker, Roderich D. Süssmuth and Sónia Mendo


This study demonstrated, for the first time, that immunity genes licFGEHI are not essential for self-protection and production of the two-component lantibiotic lichenicidin in the Gram-negative heterologous host Escherichia coli BLic5. Additionally, it was experimentally demonstrated that lichenicidin lantibiotics are active against the E. coli imp4213 strain, a mutant strain possessing a permeable outer membrane

Topics: Genetics and Molecular Biology
Publisher: American Society for Microbiology
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Provided by: PubMed Central
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