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Local Application of BMP-2 Specific Plasmids in Fibrin Glue does not Promote Implant Fixation

By Benjamin Faensen, Britt Wildemann, Christian Hain, Julius Höhne, Yvonne Funke, Christan Plank, Axel Stemberger and Gerhard Schmidmaier
Topics: Research Article
Publisher: BioMed Central
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Provided by: PubMed Central

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  1. (2002). A new electrochemically graded hydroxyapatite coating for osteosynthetic implants promotes implant osteointegration in a rat model.
  2. (2002). Accelerated and improved osteointegration of implants biocoated with bone morphogenetic protein 2 (BMP-2).
  3. (2006). AW: Effect of BMP-2 gene transfer on bone healing in sheep. Gene Ther
  4. (2008). C: A fibrin glue composition as carrier for nucleic acid vectors. Pharm Res
  5. (1999). CH: A gene therapy approach to accelerating bone healing. Evaluation of gene expression in a New Zealand white rabbit model. Knee Surg Sports Traumatol Arthrosc
  6. (2007). Current and future clinical applications of bone morphogenetic proteins in orthopaedic trauma surgery. Int Orthop
  7. (2010). DJ: A population-based study of trends in the use of total hip and total knee arthroplasty, 1969-2008. Mayo Clin Proc
  8. (2007). EB: The influence of BMP-2 and its mode of delivery on the osteoconductivity of implant surfaces during the early phase of osseointegration. Biomaterials
  9. (2008). Eckelt U: Evaluation of osseointegration of dental implants coated with collagen, chondroitin sulphate and BMP-4: an animal study. Int J Oral Maxillofac Surg
  10. (2009). Einhorn TA: Bone morphogenetic proteins in orthopaedic surgery. Cytokine Growth Factor Rev
  11. (2004). GR: Bone morphogenetic proteins. Growth Factors
  12. (1999). Griss P: Implant fixation by bone ingrowth.
  13. (2006). H: [BMP and osteoclastogenesis]. Clin Calcium
  14. (2007). Herberts : Swedish Hip Arthroplasty Register - Annual Report
  15. (2004). Hydroxyapatite-coated prostheses in total hip and knee arthroplasty.
  16. (2003). Improved osseointegration of titanium implants of different surface characteristics by the use of bone morphogenetic protein (BMP-3): an animal study performed at the metaphyseal bone bed in dogs]. Z Orthop Ihre Grenzgeb
  17. (2004). JM: Locally delivered rhBMP-2 enhances bone ingrowth and gap healing in a canine model.
  18. (2006). LD: Design of modular non-viral gene therapy vectors. Biomaterials
  19. (1986). Maniatopoulos C: Observations on the effect of movement on bone ingrowth into porous-surfaced implants. Clin Orthop Relat Res
  20. (2002). Morphogenetic Proteins. In Principles of Bone Biology. Edited by: Bilezikian JP RLRG. San Diego, CA:
  21. (2001). N: Bone morphogenetic protein 2 stimulates osteoclast differentiation and survival supported by receptor activator of nuclear factor-kappaB ligand. Endocrinology
  22. (2009). Nonviral gene delivery: principle, limitations, and recent progress.
  23. (2002). Nonviral vector loaded collagen sponges for sustained gene delivery in vitro and in vivo.
  24. (2000). Osseointegration: a reality. Periodontol
  25. (2007). Osteogenic protein-1 increases the fixation of implants grafted with morcellised bone allograft and ProOsteon bone substitute: an experimental study in dogs. J Bone Joint Surg Br
  26. (2005). Osteointegration of hydroxyapatite-titanium implants coated with nonglycosylated recombinant human bone morphogenetic protein-2 (BMP-2) in aged sheep.
  27. (2010). Picavet HS: [Trends in the number of knee and hip arthroplasties: considerably more knee and hip prostheses due to osteoarthritis in 2030]. Ned Tijdschr Geneeskd
  28. (2000). Protective copolymers for nonviral gene vectors: synthesis, vector characterization and application in gene delivery. Gene Ther
  29. (2002). SE: Changing incidence of primary total hip arthroplasty and total knee arthroplasty for primary osteoarthritis.
  30. (2002). Soballe K: Osteogenic protein 1 device increases bone formation and bone graft resorption around cementless implants. Acta Orthop Scand
  31. (2006). Tsumaki N: Bone morphogenetic proteins in bone stimulate osteoclasts and osteoblasts during bone development.
  32. (2008). Uncemented stems in hip replacement– hydroxyapatite or plain porous: does it matter? Based on a prospective study of HA Omnifit stems at 15-years minimum follow-up. Hip Int
  33. (2010). Virdi AS: Effect of recombinant human transforming growth factor-beta2 dose on bone formation in rat femur titanium implant model.
  34. (2003). WH: The efficacy of BMP-2 to induce bone ingrowth in a total hip replacement model. Clin Orthop Relat Res