Article thumbnail

Comparing the effects of desflurane and isoflurane on middle ear pressure



The aim of this study was to determine middle ear pressure changes during the operation performed under anaesthesia induced by isoflurane or desflurane. This was a prospective, case–control study. A total of 38 children with no middle ear pathology scheduled for inguinal hernia surgery were included in the study. Group I (n = 22) received isoflurane and Group II (n = 16) received desflurane. Baseline tympanometry was performed before the anaesthesia on both ears, and tympanometry was repeated 5, 10 and 15 minutes after the administration and 10 and 30 minutes after the withdrawal of anaesthetic agents. Data were analyzed using the Mann-Whitney U (inter-group) and the Wilcoxon test (intra-group) procedures. The mean middle ear pressure values in the 44 ears of the 22 children in Group I and the 32 ears of the 16 children in Group II did not show any significant difference before the anaesthesia by either anaesthetic agent (p > 0.05). Increase in the mean middle ear pressure values at the 5th and 10th minute of the operation was significant different between both groups (2.84 and 5.80 daPa for isoflurane; 59.06 and 72.81 daPa for desflurane; p ≤ 0.05). Desflurane is more increased than isoflurane on intra-tympanic pressure and isoflurane may be used more safely than desflurane in middle ear operations. The low effect of isoflurane on intra-tympanic pressure can be explained by the high blood/gas partition coefficient compared to desflurane

Topics: Otology
Publisher: Pacini Editore SpA
OAI identifier:
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles


  1. (2010). 2nd. Partition coefficients of 1-653 in human blood, saline, and olive oil. Anesth Analg 1987;66:971-3. received: march 9,
  2. Arnfred i. Middle ear pressure variations during anesthesia.
  3. Complications of using laryngeal mask airway during anaesthesia in patients undergoing major ear surgery. Acta otorhinolaryngol ital
  4. Desflurane versus sevoflurane to reduce blood loss in maxillofacial surgery.
  5. Ear injury caused by elevated intratympanic pressure during general anaesthesia.
  6. Effect of nitrous oxide on middle ear pressure: a comparison between inhalational anaesthesia with nitrous oxide and TIVA.
  7. Effects of desflurane on middle ear pressure.
  8. Effects of sevoflurane and TIVA with propofol on middle ear pressure.
  9. Middle ear pressure changes during anesthesia with or without nitrous oxide are similar among airway devices. Anesth Analg
  10. Middle ear pressure variation: effect of nitrous oxide. laryngoscope
  11. nishihara l, hanada r, et al. Two cases of hearing disorder following general anesthesia. masui
  12. normandin n, Plamondon l, et al. Tympanic membrane rupture after anesthesia with nitrous oxide.
  13. Pharmacokinetics of inhaled anesthetics in humans: measurements B. Acar et al. during and after simultaneous administration of enflurane, halothane, isoflurane, methoxyflurane, and nitrous oxide.
  14. Studies in impedance audiometry. I. Normal and sensorineural ears.
  15. Taheri S, eger ei 2nd, et al. Visceral losses of desflurane, isoflurane, and halothane in swine.