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Familial neuralgia of occipital and intermedius nerves in a Chinese family

By Yu Wang, Chuan-Yong Yu, Lin Huang, Franz Riederer and Dominik Ettlin

Abstract

Cranial nerve neuralgia usually occurs sporadically. Nonetheless, familial cases of trigeminal neuralgia are not uncommon with a reported incidence of 1–2%, suggestive of an autosomal dominant inheritance. In contrast, familial occipital neuralgia is rarely reported with only one report in the literature. We present a Chinese family with five cases of occipital and nervus intermedius neuralgia alone or in combination in three generations. All persons afflicted with occipital neuralgia have suffered from paroxysmal ‘electric wave’-like pain for years. In the first generation, the father (index patient) was affected, in the second generation all his three daughters (with two sons spared) and in the third generation a daughter’s male offspring is affected. This familial pattern suggests an X-linked dominant or an autosomal dominant inheritance mode

Topics: Brief Report
Publisher: Springer Milan
OAI identifier: oai:pubmedcentral.nih.gov:3139053
Provided by: PubMed Central

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Citations

  1. (1940). An analysis of 1,433 cases of paroxysmal trigeminal neuralgia and the end results of gasserian alcohol injection.
  2. (2005). C2 myelitis presenting with neuralgiform occipital pain.
  3. Cerbo R (2007)Neurovascularheadacheandoccipitalneuralgiasecondaryto bleeding of bulbocervical cavernoma.
  4. (2010). Classification ICHD-II. Cranial neuralgias and central causes of facial pain http://ihs-classification.org/en/02_klassifika tion/04_teil3/13.00.00_facialpain.html (viewed 3
  5. (2007). Craniocervical junction schwannoma mimicking occipital neuralgia.
  6. (2004). Electrophysiological properties of mutant Nav1.7 sodium channels in a painful inherited neuropathy.
  7. (2010). Familial occipital and nervus intermedius neuralgia in a Swiss family.
  8. (2003). Familial trigeminal neuralgia: case reports and review of the literature.
  9. (2010). Microvascular decompression of the anterior inferior cerebellar artery for intermediate nerve neuralgia.
  10. (2003). MuelaMolinero A
  11. (2002). Occipital neuralgia as isolated symptom of an upper cervical cavernous angioma.
  12. (2009). Occipital neuralgia as the only presenting symptom of foramen magnum meningioma.
  13. (2005). Occipital neuralgia secondary to respiratory tract infection.
  14. (2008). Occipital neuralgia with cervical myelitis.
  15. (2001). Osteochondroma of the cervical spine causing occipital nerve neuralgia. Case report.
  16. (2009). Voltage-gated sodium channels: therapeutic targets for pain. Pain Med