(1999). Analysis of DNAprotein crosslinking activity of malondialdehyde in vitro.
and Pommier,Y.(2008)ThemodulationoftopoisomeraseI-mediatedDNA cleavage and the induction of DNA-topoisomerase I crosslinks by crotonaldehyde-derivedDNAadducts.NucleicAcidsRes.36,4128–4136.
(2001). Carbinolamines, imines, and oxazolidines from ﬂuorinated propranolol analogs. 19F NMR and mass spectral characterization and evidence for formation1133 dx.doi.org/10.1021/tx200113n |Chem.
(1977). Carbon-13 nuclear magnetic resonance studies of vitamin B6 Schiﬀ base and carbinolamine formation in aqueous solution. 1. The adduct of pyridoxal 50-phosphate and DL-alanine.
(1969). Catalysis in Chemistry and Enzymology,
Cavaluzzi,M.J.,andBorer,P.N.(2004)RevisedUVextinction coeﬃcients for nucleoside-50-monophosphates and unpaired DNA and RNA.
(2008). Chemical propertiesofoxopropenyladductsofpurineandpyrimidinenucleosides andtheirreactivitytowardaminoacidcross-linkformation.J.Am.Chem.
Clastosome: A subtypeof nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome.
(2001). Covalent intermediate trapped in 2-keto-3-deoxy-6- phosphogluconate (KDPG) aldolase structure at 1.95-A resolution.
cross-links induced by R,β-unsaturated aldehydes derived from lipid peroxidation and environmental sources.
Crystal structure of decameric fructose-6-phosphate aldolase from Escherichia coli reveals inter-subunit helix swapping as a structural basis for assembly diﬀerences in the transaldolase family.
Desai,S.D.,Liu,L.F.,Vazquez-Abad,D.,andD’Arpa,P.(1997) Ubiquitin-dependentdestructionoftopoisomeraseIisstimulatedbythe antitumor drug camptothecin.
(1996). Detection of 1,N 2-propanodeoxyguanosine adducts as potential endogenous DNA lesions in rodent and human tissues.
(2002). Detection of an interchain carbinolamine cross-link formed in a CpG sequence by the acrolein DNA adduct γ-OH-1,N 2-propano-20-deoxyguanosine.
(1994). Detection of exocyclic 1, N 2-propanodeoxyguanosine adducts as common DNA lesions in rodents and humans.
(2002). DNA adducts of acrolein: Site-speciﬁc synthesis of an oligodeoxynucleotide containing 6-hydroxy-5,6,7,8-tetrahydropyrimido[1,2-a]purin-10(3H)-one, an acrolein adduct of guanine.
(1987). DNA and RNA: NMR studies of conformations and dynamics in solution.
(2003). DNA interchain cross-links formed by acrolein and crotonaldehyde.
(1997). DNA-protein cross-links produced by various chemicals in cultured human lymphoma cells.
(2005). DNA-protein crosslinks: Their induction, repair, and biological consequences.
(1999). Endogenous formation and signiﬁcance of 1,N 2-propanodeoxyguanosine adducts.
(2004). Gaussian 03,
(1995). Improved sensitivity of HSQC spectra of exchanging protons at short iterscan delays using a new fast HSQC (FHSQC) detection scheme that avoids water saturation.
(2005). Initiation of repair of DNA-polypeptide cross-links by the UvrABC nuclease.
(2004). Interactions between UvrA and UvrB: The role of UvrB’s domain 2 in nucleotide excision repair.
(1991). Intramolecular motions of a zinc ﬁnger DNA-binding domain from Xﬁn characterized by proton-detected natural abundance 13C heteronuclear NMR spectroscopy.
Kurtz,A.J.,Dodson,M.L.,andLloyd,R.S.(2002)Evidencefor multiple imino intermediates and identiﬁcation of reactive nucleophiles in peptide-catalyzed β-elimination at abasic sites.
Lavery,R.,andSklenar,H.(1988)Thedeﬁnitionofgeneralized helicoidal parameters and of axis curvature for irregular nucleic-acids.
(2000). Loss of DNA-protein crosslinks from formaldehyde-exposed cells occurs through spontaneous hydrolysis and an active repair process linked to proteosome function.
(1994). Measuring the geometry of DNA grooves.
(2008). Mutagenic potential of DNA-peptide crosslinks mediated by acrolein-derived DNA adducts.
Nechev,L.V.,Harris,C.M.,andHarris,T.M.(2000)Synthesis of nucleosides and oligonucleotides containing adducts of acrolein and vinyl chloride.
(1989). NMR and computational characterization of the N-(deoxyguanosin-8-yl)aminoﬂuorene adduct [(AF)G] opposite adenosine in DNA: (AF)G[syn]:A[anti]pair formation and its pH dependence.
(2001). NMR characterization of a DNA duplex containing the major acrolein-derived deoxyguanosine adduct γ-OH-1,-N 2-propano-20-deoxyguanosine.
(1977). Numerical integration of cartesian equations of motion of a system with constraints: Molecular dynamics of N-alkanes.
(1980). On the mechanism of metabolic N-dealkylation. Isolation of a relatively stable carbinolamine.
(2006). Orientation of the crotonaldehyde-derived N 2-[3-Oxo-1(S)-methyl-propyl]-dG DNA adduct hinders interstrand cross-link formation in the 50-CpG-30 sequence.
(1995). Pairwise solute descreening of solute charges from a dielectric medium.
(1996). Parametrized models of aqueous free energies of solvation based on pairwise descreening of solute atomic charges from a dielectric medium.
Piotto,M.,Saudek,V.,andSklenar,V.(1992)Gradient-tailored excitation for single-quantum NMR spectroscopy of aqueous solutions.
(1999). Postsynthetic generation of a major acrolein adduct of 20-deoxyguanosine in oligomeric DNA.
(1992). Pure absorption gradient enhanced heteronuclear single quantum correlation spectroscopywithimprovedsensitivity.J.Am.Chem.Soc.114,10663–10665.
R.S.,andStone,M.P.(2009)ChemistryandbiologyofDNAcontaining 1,N 2-deoxyguanosine adducts of the R,β-unsaturated aldehydes acrolein, crotonaldehyde, and 4-hydroxynonenal.
(2008). Replication bypass of the acrolein-mediated deoxyguanine DNA-peptide cross-links by DNA polymerases of the DinB family.
(1999). Restrained molecular dynamics of solvated duplex DNA using the particle mesh Ewald method.
(1999). Role of 1,N 2-propanodeoxyguanosine adducts as endogenous DNA lesions in rodents and humans.
(1987). Sequence-speciﬁc assignments and their use in
(2003). Site-speciﬁc synthesis and reactivity of oligonucleotides containing stereochemically deﬁned 1,N 2-deoxyguanosine adducts of the lipid peroxidation product trans-4-hydroxynonenal.
Sklenar,V.,Piotto,M.,andLeppik,R.a.S.,V.(1993)GradientTailored water suppression for 1H15N HSQC Experiments optimized to retain full sensitivity.
(1997). Solution structure of the aminoﬂuorene-intercalated conformer of the syn [AF]-C8-dG adduct opposite a 2 deletion site in the NarI hot spot sequence context.
(1995). Solutionconformation of[AF]dGoppositea 2deletionsitein aDNA duplex: intercalation of the covalently attached aminoﬂuorene ring into the helix with base displacement of the C8-modiﬁed syn guanine and adjacent unpaired 30-adenine into the major groove.
Spectroscopic characterization of interstrand carbinolamine cross-links formed in the 50-CpG-30 sequence by the acrolein-derived γ-OH-1,N 2-propano-20-deoxyguanosine DNAadduct.
(2009). Stereospeciﬁc formation of the (R)-γ-hydroxytrimethylene interstrand N 2-dG:N 2-dG cross-link arising from the γ-OH-1,N 2-propano-20-deoxyguanosine adduct in the 50-CpG-30 DNA sequence.
(1995). Structural alignments of (þ)- and (-)-trans-antibenzo[a]pyrene-dG adducts positioned at a DNA template/primer junction.
Structure of an oligodeoxynucleotide containing a 1,N 2-propanodeoxyguanosine adduct positioned in a palindrome derived from the Salmonella typhimurium hisD3052 gene: Hoogsteen pairing at pH 5.2.
Subcellular localization of proteasomes and their regulatory complexes in mammalian cells.
(2005). Synthesis and properties of an acetaldehyde-derived oligonucleotide interstrand cross-link.
(1992). The three-dimensional structure in solution (pH 5.8) of a DNA 9-mer duplex containing 1,N 2-propanodeoxyguanosine opposite deoxyadenosine. Restrained molecular dynamics and NOE-based reﬁnement calculations.
(2001). The x-ray structure of yeast 5-aminolaevulinic acid dehydratase complexed with substrate and three inhibitors.