Article thumbnail

Successful Treatment of Protein-Losing Gastroenteropathy with Steroid Pulse and Immunosuppressive Therapies in a Patient with Sjögren Syndrome

By Tetsushi Nasu, Kaori Miyata, Akiko Uno, Akira Kawashima, Michi Kondo, Takashi Akamizu and Taisei Nakao


We report the case of a 59-year-old female who developed facial edema together with hypoproteinemia. On the basis of 99mTc-human serum albumin scintigraphy and a1-antitrypsin clearance, she was diagnosed with protein-losing gastroenteropathy. Furthermore, she was diagnosed with Sjögren syndrome on the basis of eye and oral dryness, positive result with anti-SSA antibody, and salivary gland biopsy. Her symptoms improved with the use of immunosuppressive agents following steroid pulse therapy. Therefore, steroid pulse therapy and immunosuppressive agents should be considered as possible effective treatment strategies for protein-losing gastroenteropathy associated with autoimmune diseases

Topics: Published Online: July 2011
Publisher: S. Karger AG
OAI identifier:
Provided by: PubMed Central

Suggested articles


  1. al: Faecal clearance of alpha 1-antitrypsin reflects disease activity and correlates with rapid turnover proteins in chronic inflammatory bowel disease.
  2. (1991). al: Protein losing enteropathy associated with collagen disease. Ann Rheum Dis
  3. (1989). al: Protein-losing enteropathy in association with immune deposits in gastrointestinal mucosal capillaries.
  4. al: Protein-losing enteropathy with hypocomplementemia and antinuclear antibodies.
  5. (2009). al: Protein-losing gastroenteropathy associated with primary Sjögren’s syndrome: a characteristic oriental variant. Rheumatol Int
  6. al: The occurrence of malignancies in patients with rheumatoid arthritis treated with cyclophosphamide: a controlled retrospective follow-up. Ann Rheum Dis 1983;42:
  7. Basic and clinical aspects of intestinal lymphatics.
  8. et al: Mixed connective tissue disease associated with protein losing enteropathy: successful treatment with intravenous cyclophosphamide therapy. Intern Med 1992;31:
  9. (2006). et al: Outcome of protein-losing gastroenteropathy in systemic lupus erythematosus treated with prednisolone and azathioprine. Rheumatology
  10. (2005). et al: Protein-losing enteropathy associated with systemic lupus erythematosus response to cyclophosphamide. Rheumatol Int
  11. et al: The mechanism of hypoproteinemia in patients with regional enteritis and ulcerative colitis.
  12. et al: Usefulness of initial histological features for stratifying Sjogren’s syndrome responders to mizoribine therapy. Rheumatology
  13. JH: A case of unexplained gastrointestinal protein loss.
  14. (1971). Pinals RS: Protein-losing enteropathy in systemic lupus erythematosus.
  15. Protein-losing enteropathy.

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.