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Epithelial Cells Lining Salivary Gland Ducts Are Early Target Cells of Severe Acute Respiratory Syndrome Coronavirus Infection in the Upper Respiratory Tracts of Rhesus Macaques ▿

By Li Liu, Qiang Wei, Xavier Alvarez, Haibo Wang, Yanhua Du, Hua Zhu, Hong Jiang, Jingying Zhou, Pokman Lam, Linqi Zhang, Andrew Lackner, Chuan Qin and Zhiwei Chen

Abstract

The shedding of severe acute respiratory syndrome coronavirus (SARS-CoV) into saliva droplets plays a critical role in viral transmission. The source of high viral loads in saliva, however, remains elusive. Here we investigate the early target cells of infection in the entire array of respiratory tissues in Chinese macaques after intranasal inoculations with a single-cycle pseudotyped virus and a pathogenic SARS-CoV. We found that angiotensin-converting enzyme 2-positive (ACE2+) cells were widely distributed in the upper respiratory tract, and ACE2+ epithelial cells lining salivary gland ducts were the early target cells productively infected. Our findings also have implications for SARS-CoV early diagnosis and prevention

Topics: Pathogenesis and Immunity
Publisher: American Society for Microbiology
OAI identifier: oai:pubmedcentral.nih.gov:3126125
Provided by: PubMed Central
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