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DARIO: a ncRNA detection and analysis tool for next-generation sequencing experiments

By Mario Fasold, David Langenberger, Hans Binder, Peter F. Stadler and Steve Hoffmann

Abstract

Small non-coding RNAs (ncRNAs) such as microRNAs, snoRNAs and tRNAs are a diverse collection of molecules with several important biological functions. Current methods for high-throughput sequencing for the first time offer the opportunity to investigate the entire ncRNAome in an essentially unbiased way. However, there is a substantial need for methods that allow a convenient analysis of these overwhelmingly large data sets. Here, we present DARIO, a free web service that allows to study short read data from small RNA-seq experiments. It provides a wide range of analysis features, including quality control, read normalization, ncRNA quantification and prediction of putative ncRNA candidates. The DARIO web site can be accessed at http://dario.bioinf.uni-leipzig.de/

Topics: Articles
Publisher: Oxford University Press
OAI identifier: oai:pubmedcentral.nih.gov:3125765
Provided by: PubMed Central

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Citations

  1. (2010). Identification and classification of small RNAs in transcriptome sequence data.