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Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation

By Robin M. Ricke, Karthik B. Jeganathan and Jan M. van Deursen

Abstract

Hyperactivated Aurora B kinase is a primary mediator of Bub1 overexpression-induced aneuploidy and tumorigenesis in mice

Topics: Research Articles
Publisher: The Rockefeller University Press
OAI identifier: oai:pubmedcentral.nih.gov:3115799
Provided by: PubMed Central

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Citations

  1. (2004). Aurora B regulates MCAK at the mitotic centromere.
  2. (2004). BubR1 insufficiency causes early onset of agingassociated phenotypes and infertility in mice.
  3. (2001). Essential roles of Drosophila inner centromere protein (INCENP) and aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregation.
  4. (2004). Karyotype analysis and interphase FISH Chromosome counts on metaphase spreads from P5 MEFs, splenocytes of 6-wk- and 5-mo-old mice, and hematopoietic cells in livers of 1-d-old mice were performed as described previously (Babu et al., 2003; Baker et al.,
  5. (2005). Reverse engineering of regulatory networks in human