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Critical comparison of diffuse reflectance spectroscopy and colorimetry as dermatological diagnostic tools for acanthosis nigricans: a chemometric approach

By Suneetha Devpura, Bensachee Pattamadilok, Zain U. Syed, Pranita Vemulapalli, Marsha Henderson, Steven J. Rehse, Iltefat Hamzavi, Henry W. Lim and Ratna Naik


Quantification of skin changes due to acanthosis nigricans (AN), a disorder common among insulin-resistant diabetic and obese individuals, was investigated using two optical techniques: diffuse reflectance spectroscopy (DRS) and colorimetry. Measurements were obtained from AN lesions on the neck and two control sites of eight AN patients. A principal component/discriminant function analysis successfully differentiated between AN lesion and normal skin with 87.7% sensitivity and 94.8% specificity in DRS measurements and 97.2% sensitivity and 96.4% specificity in colorimetry measurements

Topics: Dermatological Applications
Publisher: Optical Society of America
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Provided by: PubMed Central

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