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Interferon-γ Production by Neutrophils during Bacterial Pneumonia in Mice

By Mitsuhiro Yamada, John C. Gomez, Pauline E. Chugh, Clifford A. Lowell, Mary C. Dinauer, Dirk P. Dittmer and Claire M. Doerschuk


Rationale: Neutrophils are usually the first circulating leukocytes to respond during bacterial pneumonia. Their expression of oxidants, proteases, and other mediators present in granules is well documented, but their ability to produce mediators through transcription and translation after migration to an inflammatory site has been appreciated only more recently. Interferon (IFN)-γ is a cytokine with many functions important in host defense and immunity

Topics: E. Pulmonary Infections
Publisher: American Thoracic Society
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Provided by: PubMed Central
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