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Distinct roles of cadherin-6 and E-cadherin in tubulogenesis and lumen formation

By Liwei Jia, Fengming Liu, Steen H. Hansen, Martin B.A. ter Beest and Mirjam M.P. Zegers

Abstract

Epithelial cadherins are shown to have distinct functions. Using a three-dimensional culture system of epithelial kidney cells, it is shown that cadherin-6 acts as an inhibitor of tubulogenesis, whereas E-cadherin controls lumen formation

Topics: Articles
Publisher: The American Society for Cell Biology
OAI identifier: oai:pubmedcentral.nih.gov:3113768
Provided by: PubMed Central
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