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A yeast model for polyalanine-expansion aggregation and toxicity

By Catherine A. Konopka, Melissa N. Locke, Pamela S. Gallagher, Ngan Pham, Michael P. Hart, Claire J. Walker, Aaron D. Gitler and Richard G. Gardner

Abstract

Polyalanine expansions can result in aggregation and cause cytotoxicity. We have created the first yeast model of polyalanine-expansion aggregation and toxicity using the poly(Ade)-binding protein Pab1

Topics: Articles
Publisher: The American Society for Cell Biology
OAI identifier: oai:pubmedcentral.nih.gov:3113764
Provided by: PubMed Central
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