Article thumbnail

Dehydroepiandrosterone (DHEA) supplementation in diminished ovarian reserve (DOR)

By Norbert Gleicher and David H Barad
Topics: Review
Publisher: BioMed Central
OAI identifier:
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles


  1. (2010). A: Addition of dehydroepiandrosterone (DHEA) for poor-responder patients before and during IVF treatment improves the pregnancy rate: a randomized prospective study. Hum Reprod
  2. (2005). A: Ovarian androgens but not estrogens correlate with the degree of systemic inflammation observed during controlled ovarian stimulation. Gynecol Endocrinol
  3. (2009). A: Testosterone and dehydroepiandrosterone sulphate levels and IVF/ICSI results. Gynecol Endocrinol
  4. (1992). Abraham GE: Postmenopausal steroid replacement with micronized dehydroepiandrosterone: preliminary oral bioavailability and dose proportionality studies.
  5. (2007). Akman MA: Comparisons of follicular levels of sex steroids, gonadotropins and insulin like growth factor-1 (IGF-1) and epidermal growth factor (EGF) in poor responders and normoresponders patients undergoing ovarian stimulation with GnRH antagonist.
  6. (2008). AN: Short-term androgen priming with use of aromatase inhibitor and hCG before controlled ovarian stimulation for IVF. A randomized controlled trial. Hum Reprod
  7. (2007). Aneuploidy rates in embryos from women with prematurely declining ovarian function: a pilot study. Fertil Steril
  8. (2009). Atabekoğlu CS: Dehydroepiandrosterone supplementation improves ovarian response and cycle outcome in poor responders.
  9. (1999). Casson PR: Changes in adrenocortical function with aging and therapeutic implications. Semin Reprod Endocrinol
  10. (2009). Clinical practice. Primary ovarian insufficiency.
  11. (2006). CY: Androgen priming using aromatase inhibitor and hCG during earlyfollicular-phase GnRH antagonist down-regulation in modified antagonist protocol. Hum Reprod
  12. (1996). Delivery of dehydroepiandrosterone to premenopausal women: effect of
  13. (2010). DH: Anti-Müllerian hormone (AMH) defines, independent of age, low versus good live birth chances in women with severely ovarian reserve. Fertil Steril
  14. (2010). DH: Dehydroepiandrosterone (DHEA) reduces embryo aneuploidy: Direct evidence from preimplantation genetic screening (PGS). Reprod Biol Endocrinol
  15. (2010). DH: Improvement in diminished ovarian reserve after dehydroepiandrosterone (DHEA) supplementation. Reprod Biomed Online
  16. (2009). DH: Miscarriage rates after dehydroepiandrosterone (DHEA) supplementation in women with diminished ovarian reserve: a case control study. Reprod Biol Endocrinol
  17. (2004). Dunkel L: Effects of testosterone, dihydrotestosterone, and 17 betaestradiol on human ovarian tissue survival in culture. Fertil Steril
  18. (2006). Effect of dehydroepinadrosterone on oocytes and embryo yields, embryo grade and cell number in IVF. Hum Reprod
  19. (2006). Effects of transdermal testosterone application on the ovarian response to FSH in poor responders undergoing assisted reproduction-technique-a prospective, randomized, double-blind study. Hum Reprod
  20. (2009). Ethics Committee of the American Society for Reproductive Medicine: Fertility treatment when the prognosis is very poor or futile. Fertil Steril
  21. (2009). Evidence-based compared with reality-based medicine in obstetrics. Obstet Gynecol
  22. (2009). Evidence-based medicine under attack. Obstet Gynecol
  23. (2009). Fauser BC: Ovarian aging: mechanisms and clinical consequences. Endocr Rev
  24. (2005). FJ: Relationship between testosterone levels, insulin sensitivity, and mitochondrial function in men. Diabetes Care
  25. (2011). HA: The effect of transdermal testosterone gel pretreatment on controlled ovarian stimulation and IVF outcome in low responders. Fertil Steril
  26. (2010). Hammes SR: Granulosa cell-specific androgen receptors are critical regulators of development and function. Mol Endocrinol
  27. (2009). Ifergane G: Onset of posttraumatic seizure after dehydroepiandrosterone treatment. Fertil Steril
  28. (2007). Increased euploid embryos after supplementation with dehydroepiandrosterone (DHEA) in women with premature ovarian aging. Fertil Steril
  29. (2005). Increased oocytes production after treatment with dehydroepiandrosterone. Fertil Steril
  30. (2000). JE: Dehydroepiandrosterone supplementation augments ovarian stimulation in poor responders: a case series. Hum Reprod
  31. (1993). JE: Oral dehydroepiandrosterone in physiologic doses modulates immune function in postmenopausal women.
  32. (1996). JE: Ovarian hyperstimulation augments adrenal dehydroepiandrosterone sulfate secretion. Fertil Steril
  33. (1998). JE: Postmenopausal dehydroepiandrosterone administration increases free insulin-like growth factor-I and decreases high-density lipoprotein: a six-month trial. Fertil Steril
  34. (2001). Jr: Reproductive outcome in patients with diminished ovarian reserve. Fertil Steril
  35. (2009). L: Ovarian aging in Squirrel monkeys (Saimiri sclureus). Reproduction
  36. (2010). Lathi RB: Etiology of recurrent pregnancy loss in women over the age of 35 years. Fertil Steril
  37. (2009). LD: Secondary follicle growth and oocytes maturation by culture in alginate hydrogel following cryopreservation of the ovary or individual follicles. Biotechnol Bioeng
  38. (1985). LN: Analysis of nonprescription capsules purported to contain an androgen.
  39. (2008). Lossi K: Increased intrafollicular androgen levels affect human granulose secretion of anti-Müllerian hormone and inhibin-B. Fertil Steril
  40. (2009). Mamas E: Dehydroepiandrosterone supplementation in assisted reproduction: rational and results. Curr Opin Obstet Gynecol
  41. (2009). Mamas E: Premature ovarian failure and dehydroepiandrosterone. Fertil Steril
  42. (2000). Maternal age and fetal loss: population register linkage study. BMJ
  43. (2006). MD: Basal and cycle androgen levels correlate with in vitro fertilization stimulation parameters but do not predict pregnancy outcome. Fertil Steril
  44. (2002). PA: Experimental evidence that changes in oocytes growth influence meiotic chromosome segregation. Hum Reprod
  45. (2009). Pellicier A: Adjuncts for ovarian stimulation: when do we adopt “orphan indications” for approved drugs. Fertil Steril
  46. (2004). Peterson EH: Effect of androgen levels on in vitro fertilization cycles. Fertil Steril
  47. (2008). Preimplantation screening: “established” and ready for prime time? Fertil Steril
  48. (2009). Premature ovarian failure and dehydroepinadrosterone. Fertil Steril
  49. (2009). Preventive Services Task Force: Folic acid supplementation for the prevention of neural tube defects: an update of the evidence for the U.S. Preventive Task Force. Ann Intern Med
  50. (2000). Reducing the risk of high-order multiple pregnancy after ovarian stimulation with gonadotropins.
  51. (2009). RF: Follicular conditioning with dehydroepiandrosterone co-treatment improves IUI outcome in clomiphene citrate patients.
  52. (2010). RF: The use of mitochondrial nutrients to improve the outcome of infertility treatment in older patients. Fertil Steril
  53. (1995). RG: A mathematical model of follicle dynamics in the human ovary. Hum Reprod
  54. (2008). Rizzello F: Ovarian reserve.
  55. (2007). S: Dehydroepiandrosterone for systemic lupus erythematosus. Cochrane Database Syst Rev
  56. (2009). S: Pharamcokinetiks of dehydroepiandrosterone and its metabolites after long-term oral dehydroepiandrosterone treatment in postmenopausal women. Menopause
  57. (2009). SR: The safety of 52 weeks of oral DHEA therapy for postmenopausal women. Maturitas
  58. Survey: Poor responders: How to define, diagnose and treat?[
  59. (2006). The effects of dexamethasone and dehydroepiandrosterone (DHEA) on cytokines and receptor expression in a human osteoblastic cell line: potential steroid-sparing role of DHEA. Cytokine
  60. (1982). The role of androgens in follicular development in the ovary. I. A quantitative analysis oocytes ovulation. J Exp Zoology
  61. (2007). Too old for IVF: are we discriminating against older women? J Assist Reprod Genet
  62. (2009). Transdermal testosterone may improve ovarian response to gonadotrophins in low-responder IVF patients: a randomized, clinical trial. Hum Reprod
  63. (2007). Update on the use of dehydroepiandrosterone supplementation among women with diminished ovarian function.