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Pharmacological Cholinergic Blockade Stimulates Inflammatory Cytokine Production and Lymphocytic Infiltration in the Mouse Lacrimal Gland

By John D. Pitcher, Cintia S. De Paiva, Flavia S. A. Pelegrino, Andrew J. McClellan, Jagdeep K. Raince, Solherny B. Pangelinan, Ehsan Rahimy, William J. Farley, Michael E. Stern, De-Quan Li and Stephen C. Pflugfelder


It is now recognized that patients with the severe autoimmune dry eye condition Sjögren's syndrome have significantly higher levels of M3 acetylcholine receptor autoantibodies that have been shown to impair lacrimal gland secretion. The authors found that inhibition of mouse lacrimal secretory function by systemic cholinergic blockade resulted in massive glandular cellular infiltrate with an elevation of a mix of inflammatory cytokines

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Publisher: Association for Research in Vision and Ophthalmology, Inc.
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