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Hyperosmotic Stress-Induced Corneal Epithelial Cell Death through Activation of Polo-like Kinase 3 and c-Jun

By Ling Wang, Wei Dai and Luo Lu

Abstract

High extracellular osmotic pressure causes stress to corneal epithelial wound healing. The present study demonstrates a novel signaling mechanism in addition to stress-induced MAPK pathways in human corneal epithelial cells to regulate the AP-1 transcription complex through the activation of Plk3, resulting in changes of cell fate

Topics: Articles
Publisher: Association for Research in Vision and Ophthalmology, Inc.
OAI identifier: oai:pubmedcentral.nih.gov:3109023
Provided by: PubMed Central
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