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Multiple Phenotypes in Adult Mice following Inactivation of the Coxsackievirus and Adenovirus Receptor (Car) Gene

By Ahmad Pazirandeh, Taranum Sultana, Momina Mirza, Björn Rozell, Kjell Hultenby, Karin Wallis, Björn Vennström, Ben Davis, Anders Arner, Rainer Heuchel, Matthias Löhr, Lennart Philipson and Kerstin Sollerbrant


To determine the normal function of the Coxsackievirus and Adenovirus Receptor (CAR), a protein found in tight junctions and other intercellular complexes, we constructed a mouse line in which the CAR gene could be disrupted at any chosen time point in a broad spectrum of cell types and tissues. All knockouts examined displayed a dilated intestinal tract and atrophy of the exocrine pancreas with appearance of tubular complexes characteristic of acinar-to-ductal metaplasia. The mice also exhibited a complete atrio-ventricular block and abnormal thymopoiesis. These results demonstrate that CAR exerts important functions in the physiology of several organs in vivo

Topics: Research Article
Publisher: Public Library of Science
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Provided by: PubMed Central

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