Article thumbnail

Hepatocyte growth factor incorporated chitosan nanoparticles augment the differentiation of stem cell into hepatocytes for the recovery of liver cirrhosis in mice

By Sivasami Pulavendran, Chellan Rose and Asit Baran Mandal
Topics: Research
Publisher: BioMed Central
OAI identifier:
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles


  1. (2003). A: Hepatocyte growth factor gene therapy accelerates regeneration in cirrhotic mouse liver after hepatectomy. Gut
  2. (1999). AJ: CD34 +hematopoietic stem cells exert accessory function in lipopolysaccharide-induced T cell stimulation and CD80 expression on monocytes. J Exp Med
  3. (2002). Alonso MJ: Design of biodegradable particles for protein delivery.
  4. (2007). Alonso MJ: Novel hydrophilic chitosan-polyethylene oxide nanoparticles as protein carriers.
  5. (2007). Anti-inflammation role for mesenchymal stem cells transplantation in myocardial infarction. Inflammation
  6. (2003). Buylla AA: Fusion of bone marrow derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Nature
  7. (2003). Cell fusion is the principal source of bone marrow derived hepatocytes. Nature
  8. (2002). Cui FD: Bioadhesivepolysaccharide in protein delivery system: chitosan nanoparticles improve the intestinal absorption of insulin in vivo.
  9. (2004). D: In vivo contribution of murine mesenchymal stem cells into multiple cell-types under minimal damageconditions.
  10. (2001). De Sanchez VC: Adenosine reverses a pre-established CCl4-induced micronodular cirrhosis through enhancing collagenolytic activity and stimulating hepatocyte cell proliferation in rats. Hepatol
  11. (2010). Differential anti-inflammatory and antifibrotic activity of transplanted mesenchymal vs. hematopoietic stem cells in carbon tetrachloride-induced liver injury in mice. Int Immunopharmacol
  12. (1999). DR: Multilineage potential of adult human mesenchymal stem cells. Science
  13. (2003). DW: Transplanted bone marrow regenerates liver by cell fusion. Nature
  14. (2003). Dzau VJ: Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infracted hearts. Nat Med
  15. (2003). Estrov Z: Transdifferentiation of human peripheral blood CD34+enriched cell population into cardiomyocytes, endothelial cells, and smooth muscle cells in vivo. Circulation
  16. (2008). Geertsma R: Particlesizedependent organ distribution of gold nanoparticles after intravenous administration. Biomaterials
  17. (2005). Growth inhibition and apoptosis in liver myofibroblasts promoted by hepatocyte growth factor leads to resolution from liver cirrhosis.
  18. (2000). H: In vivo transfer of hepatocyte growth factor gene accelerates Pulavendran et al.
  19. (1999). Hepatocyte growth factor gene therapy of liver cirrhosis in rat. Nat Med
  20. (2010). Hepatocyte growth factor incorporated chitosan nanoparticles differentiate murine bone marrow mesenchymal stem cell into hepatocytes in vitro.
  21. (1994). Hepatocyte growth factor prevents acute renal failure and accelerates renal regeneration inmice.
  22. (1998). Hepatocyte growth factor promotes liver regeneration with prompt improvement of hyper-bilirubinemia in hepatectomized cholestatic rats.
  23. (2005). Humanmesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion. Blood
  24. (2007). Immunomodulation of activated hepatic stellate cells by mesenchymal stem cells. Biochem Biophys Res Commun
  25. (1999). Leong KW: Oral gene delivery with chitosanDNA nanoparticles generates immunologic protection in a murine model of peanut allergy. Nat Med
  26. (1950). MA: The determination of collagen and elastin in tissues.
  27. (2006). Mechanisms of liver fibrosis. Clin Chim Acta
  28. (2003). Mesenchymal stem cells distribute to a wide range of tissues following systemic infusion into non-human primates. Blood
  29. (2007). MMP-2, MT1-MMP, and TIMP-2 are essential for the invasive capacity of human mesenchymal stem cells: differential regulation by inflammatory cytokines. Blood
  30. (2001). multi-lineage engraftment by a single bone marrow derivedstem cells. Cell
  31. (2003). Nolta JA: Albumin expressing hepatocyte-like cells develops in the livers of immunedeficientmice transplantation with highly purified human hematopoietic stem cells. Blood
  32. (2006). Preparation and characterization of protein-loaded N-trimethyl chitosan nanoparticles as nasal delivery system.
  33. (2003). Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med
  34. (2007). Ringde O: Immunomodulation by mesenchymal stem cells and clinical experience.
  35. (1995). S: Hepatocyte growth factor stimulates liver regeneration and elevates blood protein level in normal and partially hepatectomized rats.
  36. (2007). SJ: Bone marrow stem cells and liver disease. Gut
  37. (1992). T: Direct evidence that hepatocyte growth factor is a hepatotrophic factor for liver regeneration and has a potent anti-hepatitis effect in vivo. Hepatol
  38. (2005). Tsubouchi H: Hepatocyte growth factor accelerates the proliferation of hepatic oval cells and possibly promotes the differentiation in a 2-acetylaminofluorene/partial hepatectomy model in rats. J Gastro Hepato
  39. (2005). Uccelli A: Mesenchymal stem cells ameliorate experimental autoimmuneencephalomyelitis inducing T-cell anergy. Blood
  40. (2003). Verma IM: Little evidence of bone marrowderivedhepatocytes in the replacement of injured liver.
  41. (2003). Wang LS: Treatment of myocardial ischemia with bone marrow derived mesenchymal stem cells over expressing hepatocyte growth factor. Mol Ther