Article thumbnail

How much do you know about benign, preneoplastic, non-invasive and invasive neoplastic lesions of the urinary bladder classified according to the 2004 WHO scheme?

By Rodolfo Montironi, Liang Cheng, Marina Scarpelli, Roberta Mazzucchelli and Antonio Lopez-Beltran


The aim of this essay is the self assessment of the level of knowledge of the 2004 WHO classification of bladder neoplasms through a series of MCQs, each associated a short commentary. This paper is directed to all who are involved with the application of this classification at the anticancer research, diagnostic, prognostic and therapeutic levels, in particular to uropathologists, urologists and oncologists

Topics: Commentary
Publisher: BioMed Central
OAI identifier:
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles


  1. (2006). Cheng L: Inverted papilloma of the urinary bladder: a molecular genetic appraisal. Mod Pathol
  2. (2002). Comparison of WHO/ISUP and WHO classification of noninvasive papillary urothelial neoplasms for risk of progression. Urology
  3. (2010). Conventional morphologic, prognostic, andpredictive factors and reporting of bladder cancer.
  4. (2007). Histologic grading of noninvasive papillary urothelial neoplasms. Eur Urol
  5. (2000). Intravesical adipose tissue: a quantitative study of its presence and location with implications for therapy and prognosis. Am J Surg Pathos
  6. (1989). JS: The morphology of normal human bladder urothelium.
  7. Lopez-Beltran A: Staging and reporting of urothelial carcinoma of the urinary bladder. Mod Pathol 2009, 22(Suppl 2):S70-S95.
  8. (2004). Lopez-Beltran A: The
  9. (2001). MB: Discriminatory immunohistochemical staining of urothelial carcinoma in situ and non neoplastic urothelium. An analysis of cytokeratin 20, p53, and CD44 antigens.
  10. (2000). MB: pT1 urothelial carcinoma of the bladder: criteria for diagnosis, pitfalls, and clinical implications. Adv Anat Pathol
  11. (2008). Morphological classification and definition of benign, preneoplastic and non-invasive neoplastic lesions of the urinary bladder. Histopathology
  12. (1998). Mostofi FK: The World Health Organization/International Society of Urological Pathology consensus classification of urothelial (transitional cell) neoplasms of the urinary bladder.
  13. (2005). To KF: Is surveillance necessary for inverted papilloma in the urinary bladder and urethra?
  14. Tumours of the urinary system.
  15. (2010). Urothelial dysplasia and other flat lesions of the urinary bladder: clinicopathologic and molecular features. Hum Pathol
  16. (2011). Urothelial lesions with inverted growth patterns: histogenesis, molecular genetic findings, differential diagnosis and clinical management.