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Photosensitizers for photodynamic therapy: One-pot heterogeneous catalytic transfer reduction of porphyrins

By Amadeu F. Brigas, Ana M. Rosa da Costa, Arménio C. Serra and Catarina Pires

Abstract

A number of new porphyrin-based photosensitizers have been developed for Photodynamic Therapy (PDT) in recent years. Chlorins, which are a reduced form of porphyrins, show better potential of application since they have a stronger absorption band on the red region of the visible spectrum and, hence, a deeper penetration into tissues. We found that by using heterogeneous catalytic transfer reduction (CTR), meso-tetraphenylporphyrin (TPP) could be hydrogenated, although in modest yields, to meso-tetraphenylchlorin (TPC) in a single reaction step. Best reaction conditions were attained using formic acid or sodium phosphinate/water as hydrogen donors, tetrahydrofuran (THF) or toluene as solvent and 10% palladium on charcoal as catalyst

Topics: Short Communication
Publisher: Medknow Publications Pvt Ltd
OAI identifier: oai:pubmedcentral.nih.gov:3103927
Provided by: PubMed Central
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