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Grb2 regulates B-cell maturation, B-cell memory responses and inhibits B-cell Ca2+ signalling

By Jochen A Ackermann, Daniel Radtke, Anna Maurberger, Thomas H Winkler and Lars Nitschke

Abstract

Grb2 regulates B-cell maturation, B-cell memory responses and inhibits B-cell Ca2+ signalling. The adaptor protein Grb2 regulates different signalling pathways, but its role in primary B cells is not known. Using B-cell-specific Grb2-deficient mice, the findings show that Grb2 is important for the development of mature B cells and memory B-cell function

Topics: Article
Publisher: Nature Publishing Group
OAI identifier: oai:pubmedcentral.nih.gov:3102284
Provided by: PubMed Central
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