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Endocytosis of EphA receptors is essential for the proper development of the retinocollicular topographic map

By Sooyeon Yoo, Yujin Kim, Hyuna Noh, Haeryung Lee, Eunjeong Park and Soochul Park


Rac-mediated internalization of the Eph receptor and its ligand ephrin is required for proper axonal guidance in vivo. Eph receptor/ephrin endocytosis reduces adhesive contacts between axons and their substrate, leading to axon retraction

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Publisher: Nature Publishing Group
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Provided by: PubMed Central
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