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Endocytosis of EphA receptors is essential for the proper development of the retinocollicular topographic map

By Sooyeon Yoo, Yujin Kim, Hyuna Noh, Haeryung Lee, Eunjeong Park and Soochul Park

Abstract

Rac-mediated internalization of the Eph receptor and its ligand ephrin is required for proper axonal guidance in vivo. Eph receptor/ephrin endocytosis reduces adhesive contacts between axons and their substrate, leading to axon retraction

Topics: Article
Publisher: Nature Publishing Group
OAI identifier: oai:pubmedcentral.nih.gov:3102278
Provided by: PubMed Central
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