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Lack of TNF-α Promotes Caspase-3–Independent Apoptosis during Murine Cytomegalovirus Retinitis

By Ming Zhang, Jason Covar, Brendan Marshall, Zheng Dong and Sally S. Atherton


Both caspase-dependent and caspase-independent apoptosis contribute to retinal damage during murine cytomegalovirus retinitis, and TNF-α is among the inducers of apoptosis. These studies suggest that TNF-α may play both apoptotic and antiapoptotic roles, depending on the stage of infection

Topics: Articles
Publisher: Association for Research in Vision and Ophthalmology, Inc.
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Provided by: PubMed Central
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