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Upregulation of Mouse Genes in HSV-1 Latent TG after Butyrate Treatment Implicates the Multiple Roles of the LAT-ICP0 Locus

By Christian Clement, Partha S. Bhattacharjee, Manish Kumar, Timothy P. Foster, Hilary W. Thompson and James M. Hill

Abstract

Sodium butyrate–induced reactivation of HSV-1 caused significant moderation of specific host epigenetic changes and failed to elicit or suppress immune activity. The relative silencing of immune activity could be valuable in developing novel therapies for HSK and viral gene therapy

Topics: Articles
Publisher: Association for Research in Vision and Ophthalmology, Inc.
OAI identifier: oai:pubmedcentral.nih.gov:3101669
Provided by: PubMed Central
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