Article thumbnail

Effect of Zoledronic Acid on Acro-Osteolysis and Osteoporosis in a Patient with Hajdu-Cheney Syndrome

By Sena Hwang, Dong Yoeb Shin, Seong Hwan Moon, Eun Jig Lee, Sung-Kil Lim, Ok Hwa Kim and Yumie Rhee


Hajdu-Cheney syndrome is a rare, autosomal dominant skeletal dysplasia marked by acro-osteolysis of the distal phalanges and severe osteoporosis. Although there are more than 60 reports published to date, proper treatment and subsequent outcome have been scarce. Herein, we report a progress of anti-resorptive therapy with zoledronic acid, in a woman with Hajdu-Cheney syndrome. Results suggest that anti-resorptive therapy may be important in delaying the progress of osteoporosis and preventing fractures, but not necessarily acro-osteolysis itself

Topics: Case Report
Publisher: Yonsei University College of Medicine
OAI identifier:
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles


  1. (1948). Cranio-skeletal dysplasia.
  2. (1990). High turnover osteoporosis in acro-osteolysis (Hajdu-Cheney syndrome).
  3. Severe osteoporosis in familial Hajdu-Cheney syndrome: progression of acro-osteolysis and osteoporosis during
  4. (1990). The Hajdu-Cheney syndrome: a case report and review of the literature. Pediatr Radiol