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Parkin Mediates Apparent E2-Independent Monoubiquitination In Vitro and Contains an Intrinsic Activity That Catalyzes Polyubiquitination

By Katherine C. M. Chew, Noriyuki Matsuda, Keiko Saisho, Grace G. Y. Lim, Chou Chai, Hui-Mei Tan, Keiji Tanaka and Kah-Leong Lim
Topics: Research Article
Publisher: Public Library of Science
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Provided by: PubMed Central

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  10. (2004). Definitive evidence for Ufd2-catalyzed elongation of the ubiquitin chain through Lys48 linkage.
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  23. (2000). Parkin suppresses unfolded protein stressinduced cell death through its E3 ubiquitin-protein ligase activity.
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  25. (2006). Parkin: a multifaceted ubiquitin ligase.
  26. (2007). Parkinmediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6.
  27. (2010). Phosphorylation of parkin by Parkinson diseaselinked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling.
  28. (2007). Phosphorylation of Parkin by the cyclin-dependent kinase 5 at the linker region modulates its ubiquitin-ligase activity and aggregation.
  29. (2008). PINK1 controls mitochondrial localization of Parkin through direct phosphorylation.
  30. (2010). PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy.
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  33. (2010). Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin.
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