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2-[6,8-Dibromo-3-(4-hy­droxy­cyclo­hex­yl)-1,2,3,4-tetra­hydro­quinazolin-2-yl]phenol methanol 0.25-solvate

By Zhi-Gang Wang, Rong Wang, Feng Zhi and Ming-Li Wang

Abstract

The title compound, C20H22Br2N2O2·0.25CH4O, was synthesized by the condensation reaction of salicyl­aldehyde with 4-(2-amino-3,5-dibromo­benzyl­amino)­cyclo­hexa­nol in methanol. There are four independent main mol­ecules and two half-occupied methanol solvent mol­ecules in the asymmetric unit. The dihedral angles between the two benzene rings in the four mol­ecules are 87.8 (6), 86.6 (6), 89.3 (6) and 83.1 (6)°. Each mol­ecule features an intra­molecular O—H⋯N hydrogen bond and a short N—H⋯Br link. In the crystal components are linked by O—H⋯O hydrogen bonds

Topics: Organic Papers
Publisher: International Union of Crystallography
OAI identifier: oai:pubmedcentral.nih.gov:3099869
Provided by: PubMed Central

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Citations

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  2. Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2) x y z Uiso*/Ueq Occ.
  3. (1987). The dihedral angles between the two benzene rings in the four molecules are 87.8 (6), 86.6 (6), 90.7 (6), and 96.9 (6)°, respectively. The cyclohexyl rings adopt chair configurations. All bond lengths are within normal ranges