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Immortalized, premalignant epithelial cell populations contain long-lived, label-retaining cells that asymmetrically divide and retain their template DNA

By Karen M Bussard, Corinne A Boulanger, Frances S Kittrell, Fariba Behbod, Daniel Medina and Gilbert H Smith
Topics: Research Article
Publisher: BioMed Central
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Provided by: PubMed Central

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  1. (1967). A radioautographic study of cell proliferation in the mammary gland of the pregnant mouse. Anat Rec
  2. (2010). A: Condensins promote co-orientation of sister chromatids during meiosis I in budding yeast. Genetics
  3. (2002). CA: Mammary stem cell repertoire: new insights in aging epithelial populations. Mech Ageing Dev
  4. (1984). Epithelial mouse mammary cell line exhibiting normal morphogenesis in vivo and functional differentiation in vitro.
  5. (1996). Experimental mammary epithelial morphogenesis in an in vivo model: evidence for distinct cellular progenitors of the ductal and lobular phenotype. Breast Cancer Res Treat
  6. (1984). Expression of pregnancy-specific genes in preneoplastic mouse mammary tissues from virgin mice. Cancer Res
  7. (1998). GH: An entire functional mammary gland may comprise the progeny from a single cell. Development
  8. (2008). GH: Common integration sites for MMTV in viral induced mouse mammary tumors.
  9. (2005). GH: Parity-induced mouse mammary epithelial cells are pluripotent, self-renewing and sensitive to TGF-beta1 expression. Oncogene
  10. (2002). Intestinal stem cells protect their genome by selective segregation of template DNA strands.
  11. (2002). JL: Cosegregation of chromosomes containing immortal DNA strands in cells that cycle with asymmetric stem cell kinetics. Cancer Res
  12. (2005). JL: Immortal DNA strand cosegregation requires p53/IMPDH-dependent asymmetric self-renewal associated with adult stem cells. Cancer Res
  13. (2006). Klar AJK: Cell type regulates selective segregation of mouse chromosome 7 DNA strands in mitosis. Science
  14. (2005). Label-retaining epithelial cells in mouse mammary gland divide asymmetrically and retain their template DNA strands. Development
  15. (2010). Lansdorp PM: Identification of sister chromatids by DNA template strand sequences. Nature
  16. (1991). Long-term in vivo expression of genes introduced by retrovirusmediated transfer into mammary epithelial cells.
  17. (1996). M-NI: Detection of a population of long-lived cells in mammary epithelium of the mouse. Cell Tissue Res
  18. (1975). Mutation selection and the natural history of cancer. Nature
  19. (2002). Somatic stem cells and the kinetics of mutagenesis and carcinogenesis.
  20. (2005). Support for the immortal strand hypothesis: neural stem cells partition DNA asymmetrically in vitro.
  21. (2006). Tajbakhsh S: Asymmetric division and cosegregation of template DNA strands in adult muscle satellite cells. Nat Cell Biol
  22. (1978). The segregation of DNA in epithelial stem cells. Cell
  23. (1981). TJ: Morphological evaluation of cell turnover in relation to the menstrual cycle in the ‘resting’ human breast.
  24. (1981). TJ: Ultrastructural observations on cell death by apoptosis in the ‘resting’ human breast. Virchows Arch A Pathol Anat Histol