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Ferroportin and hepcidin: a new hope in diagnosis, prognosis, and therapy for breast cancer

By Igor P Pogribny


Breast cancer is the most prevalent malignancy in women. The success of breast cancer treatment relies on the ability to detect the disease and correct molecular abnormalities at an early stage of disease development. A recent article describes a marked decrease in the levels of ferroportin in breast cancer. More importantly, the presented results demonstrate convincingly the incredible diagnostic and prognostic value of ferroportin and hepcidin gene expression in breast cancer and suggest that determination of these two molecular markers may be used as guidance toward individualized therapy for breast cancer patients

Topics: Viewpoint
Publisher: BioMed Central
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Provided by: PubMed Central

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  1. (2010). Camaschella C: Two to tango: regulation of mammalian iron metabolism. Cell
  2. (2009). DB: Cancer cell iron metabolism and the development of potent chelators as antitumour agents. Biochim Biophys Acta
  3. (2008). Does iron have a role in breast cancer? Lancet Oncol
  4. (2002). DR: The iron metabolism of neoplastic cells: alterations that facilitate proliferation? Crit Rev Oncol Hematol
  5. (2010). FM: Ferroportin and iron regulation in breast cancer progression and prognosis. Sci Transl Med
  6. (2010). Hepcidin and iron metabolism: from laboratory to clinical implications. Clin Chim Acta
  7. (2002). Ilyin G: C/EBPalpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. Cross-talk between C/EBP pathway and iron metabolism.
  8. (2010). JF: Manipulation of iron transported genes results in the suppression of human and mouse mammary adenocarcinomas. Anticancer Res
  9. (2001). JS: Role of iron in estrogen-induced cancer. Curr Med Chem
  10. (2009). Lafuse WP: Role of STAT1, NF-kappaB, and C/EBPbeta in the macrophage transcriptional regulation of hepcidin by mycobacterial infection and IFN-gamma.
  11. (2010). Pogribny IP: Role of ferritin alterations in human breast cancer cells. Breast Cancer Res Treat
  12. (2007). Rohan TE: Does excess iron play a role in breast carcinogenesis? An unresolved hypothesis. Cancer Causes Control
  13. (1997). The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells. Biochim Biophys Acta
  14. (2008). The regulation of hepcidin and its effects on systemic and cellular iron metabolism. Hematology Am Soc Hematol Educ Program