Article thumbnail

Regulation of breast cancer cell motility by T-cell lymphoma invasion and metastasis-inducing protein

By Homer C Adams, Ru Chen, Zhuoming Liu and Ian P Whitehead
Topics: Research Article
Publisher: BioMed Central
OAI identifier:
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles


  1. (2002). A: Guanine nucleotide exchange factors for Rho GTPases: turning on the switch. Genes Dev
  2. (2000). A: Rho GTPases and their effector proteins.
  3. (2002). A: Rho GTPases in cell biology.
  4. (2005). A: Rho GTPases: biochemistry and biology. Annu Rev Cell Dev Biol
  5. (2006). Androulakis II: Bone remodeling.
  6. (2009). Angiogenesis: a team effort coordinated by notch. Dev Cell
  7. (2008). B: Combined analysis of Rac1, IQGAP1, Tiam1 and E-cadherin expression in gastric cancer. Mod Pathol
  8. (2005). Cell migration during gastrulation. Curr Opin Cell Biol
  9. (1997). CJ: Dbl family proteins. Biochim Biophys Acta
  10. (2002). CJ: Tiam1 mediates Ras activation of Rac by a PI(3)Kindependent mechanism. Nat Cell Biol
  11. (1995). Collard JG: A role for Rac in Tiam1-induced membrane ruffling and invasion. Nature
  12. (1994). Collard JG: Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rholike proteins. Cell
  13. (2002). Collard JG: Mice deficient in the Rac activator Tiam1 are resistant to Rasinduced skin tumours. Nature
  14. (1995). Collard JG: Sequence of the human invasion-inducing TIAM1 gene, its conservation in evolution and its expression in tumor cell lines of different tissue origin. Oncogene
  15. (2007). Collard JG: The Par-Tiam1 complex controls persistent migration by stabilizing microtubule-dependent front-rear polarity. Curr Biol
  16. (2006). Collard JG: The rac activator Tiam1 is a Wnt-responsive gene that modifies intestinal tumor development.
  17. (2005). Condeelis JS: Tumor cells caught in the act of invading: their strategy for enhanced cell motility. Trends Cell Biol
  18. (2005). Ding YQ: Tiam1 gene expression and its significance in colorectal carcinoma.
  19. (1998). Egea G: Actin microfilaments are essential for the cytological positioning and morphology of the Golgi complex.
  20. (2001). Egea G: Actin microfilaments facilitate the retrograde transport from the Golgi complex to the endoplasmic reticulum in mammalian cells. Traffic
  21. (2002). Egea G: Regulation of protein transport from the Golgi complex to the endoplasmic reticulum by CDC42 and N-WASP. Mol Biol Cell
  22. (2008). Emigration of monocyte-derived cells to lymph nodes during resolution of inflammation and its failure in atherosclerosis. Curr Opin Lipidol
  23. (2002). Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer
  24. (2003). Feig LA: Regulation of p70 S6 kinase by complex formation between the Rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilin.
  25. (2005). Gallick GE: The guanine nucleotide exchange factor Tiam1 increases colon carcinoma growth at metastatic sites in an orthotopic nude mouse model. Oncogene
  26. (2004). Gallick GE: The role of the guanine nucleotide exchange factor Tiam1 in cellular migration, invasion, adhesion and tumor progression. Breast Cancer Res Treat
  27. (2006). Gallick GE: Tiam1 regulates cell adhesion, migration and apoptosis in colon tumor cells. Clin Exp Metastasis
  28. (2003). GAPs galore! A survey of putative Ras superfamily GTPase activating proteins in man and Drosophila. Biochim Biophys Acta
  29. (2006). HE: Prognostic relevance of Tiam1 protein expression in prostate carcinomas.
  30. (2000). HE: Tiam1 mutations in human renal-cell carcinomas.
  31. (2003). Horwitz AR: Cell migration: integrating signals from front to back. Science
  32. (2006). IP: Bcr interacts with components of the endosomal sorting complex required for transport-I and is required for epidermal growth factor receptor turnover. Cancer Res
  33. (2002). IP: p38 MAPK-mediated activation of NF-kappaB by the RhoGEF domain of Bcr. Oncogene
  34. Isolation of Golgi membranes from tissues and cells by differential and density gradient centrifugation.
  35. (1997). JG: Regulated membrane localization of Tiam1, mediated by the NH2-terminal pleckstrin homology domain, is required for Rac-dependent membrane ruffling and C-Jun NH2-terminal kinase activation.
  36. (2005). JG: The Rac activator Tiam1 controls tight junction biogenesis in keratinocytes through binding to and activation of the Par polarity complex.
  37. (2006). JG: Tiam1 takes PARt in cell polarity. Trends Cell Biol
  38. (1992). JW: ERBB2 amplification in breast cancer analyzed by fluorescence in situ hybridization. Proc Natl Acad Sci USA
  39. (1998). Kinetic analysis of secretory protein traffic and characterization of Golgi to plasma membrane transport intermediates in living cells.
  40. (2000). KM: Localized Rac activation dynamics visualized in living cells. Science
  41. (2003). Lowe syndrome protein OCRL1 interacts with Rac GTPase in the trans-Golgi network. Hum Mol Genet
  42. (2009). Luo R: Overexpression of Tiam1 in hepatocellular carcinomas predicts poor prognosis of HCC patients.
  43. (2007). MD: MDA-MB-435 cells are derived from M14 melanoma cells: a loss for breast cancer, but a boon for melanoma research. Breast Cancer Res Treat
  44. (2009). MDA-MB-435 and M14 cell lines: identical but not M14 melanoma? Cancer Res
  45. (2005). Mechanisms of cancer cell invasion. Curr Opin Genet Dev
  46. (2007). Phosphatidylinositol-3-OH kinase or RAS pathway mutations in human breast cancer cell lines. Mol Cancer Res
  47. (2009). Progression of breast tumors is accompanied by a decrease in expression of the Rho guanine exchange factor Tiam1. Oncol Rep
  48. (2001). Ras and Rho protein induction of motility and invasion in T47 D breast adenocarcinoma cells. Methods Enzymol
  49. (2002). Regulating the actin cytoskeleton during vesicular transport.
  50. (1999). Rho guanine dissociation inhibitors: pivotal molecules in cellular signalling. Cell Signal
  51. (2001). Rodriguez-Boulan E: cdc42 regulates the exit of apical and basolateral proteins from the trans-Golgi network.
  52. (2003). Roles of Rho-family GTPases in cell polarisation and directional migration. Curr Opin Cell Biol
  53. (2003). Roovers RC, Collard JG: Regulation of Tiam1-Rac signalling.
  54. (2001). Tiam1 overexpression potentiates heregulin-induced lymphoid enhancer factor-1/beta-catenin nuclear signaling in breast cancer cells by modulating the intercellular stability.
  55. (2009). Tiam1-deficiency impairs mammary tumor formation in MMTV-c-neu but not in MMTV-c-myc mice.
  56. (2000). Translocation of the Rac1 guanine nucleotide exchange factor Tiam1 induced by platelet-derived growth factor and lysophosphatidic acid.
  57. (2003). Tumour-cell invasion and migration: diversity and escape mechanisms. Nat Rev Cancer
  58. (2005). von Andrian UH: Immune cell migration in inflammation: present and future therapeutic targets. Nat Immunol
  59. (2003). Waterman-Storer CM: Conserved microtubule-actin interactions in cell movement and morphogenesis.
  60. (2008). Wound repair and regeneration. Nature