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Non-coding RNAs as regulators of gene expression and epigenetics

By Minna U. Kaikkonen, Michael T.Y. Lam and Christopher K. Glass

Abstract

Genome-wide studies have revealed that mammalian genomes are pervasively transcribed. This has led to the identification and isolation of novel classes of non-coding RNAs (ncRNAs) that influence gene expression by a variety of mechanisms. Here we review the characteristics and functions of regulatory ncRNAs in chromatin remodelling and at multiple levels of transcriptional and post-transcriptional regulation. We also describe the potential roles of ncRNAs in vascular biology and in mediating epigenetic modifications that might play roles in cardiovascular disease susceptibility. The emerging recognition of the diverse functions of ncRNAs in regulation of gene expression suggests that they may represent new targets for therapeutic intervention

Topics: Reviews: Focus on Epigenetics and the Histone Code in Vascular Biology
Publisher: Oxford University Press
OAI identifier: oai:pubmedcentral.nih.gov:3096308
Provided by: PubMed Central
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