Article thumbnail

Heat Shock Protein 47: A Novel Biomarker of Phenotypically Altered Collagen-Producing Cells

By Takashi Taguchi, Arifa Nazneen, Abdulmonem A. Al-Shihri, Khadijah A. Turkistani and Mohammed S. Razzaque

Abstract

Heat shock protein 47 (HSP47) is a collagen-specific molecular chaperone that helps the molecular maturation of various types of collagens. A close association between increased expression of HSP47 and the excessive accumulation of collagens is found in various human and experimental fibrotic diseases. Increased levels of HSP47 in fibrotic diseases are thought to assist in the increased assembly of procollagen, and thereby contribute to the excessive deposition of collagens in fibrotic areas. Currently, there is not a good universal histological marker to identify collagen-producing cells. Identifying phenotypically altered collagen-producing cells is essential for the development of cell-based therapies to reduce the progression of fibrotic diseases. Since HSP47 has a single substrate, which is collagen, the HSP47 cellular expression provides a novel universal biomarker to identify phenotypically altered collagen-producing cells during wound healing and fibrosis. In this brief article, we explained why HSP47 could be used as a universal marker for identifying phenotypically altered collagen-producing cells

Topics: Review
Publisher: Japan Society of Histochemistry and Cytochemistry
OAI identifier: oai:pubmedcentral.nih.gov:3096080
Provided by: PubMed Central

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

Suggested articles

Citations

  1. (1962). A new puffing pattern Induced by temperature shock and DNP in Drosophila.
  2. (1998). Age-related nephropathy in the Fischer 344 rat is associated with overexpression of collagens and collagenbinding heat shock protein 47. Cell Tissue Res.
  3. (1998). Antisense oligonucleotides against collagen-binding stress protein HSP47 suppress collagen accumulation in experimental glomerulonephritis.
  4. (1998). Bleomycin-induced pulmonary fibrosis in rat is associated with increased expression of collagen-binding heat shock protein (HSP) 47. Virchows Arch.
  5. (1984). Cell surface-associated proteins which bind native type IV collagen or gelatin.
  6. (2002). Cellular and molecular events leading to renal tubulointerstitial fibrosis.
  7. (2005). Cisplatin-associated nephrotoxicity and pathological events.
  8. (2001). Co-expression of colligin and collagen in oral submucous fibrosis: plausible role in pathogenesis.
  9. (1998). Coexpression of collagens and collagen-binding heat shock protein 47 in human diabetic nephropathy and IgA nephropathy.
  10. (1987). Coexpression of keratin and vimentin in damaged and regenerating tubular epithelia of the kidney.
  11. (1994). Coexpression of the collagen-binding stress protein HSP47 gene and the alpha 1(I) and alpha 1(III) collagen genes in carbon tetrachloride-induced rat liver fibrosis.
  12. (1997). Collagen-binding heat shock protein (HSP) 47 expression in anti-thymocyte serum (ATS)-induced glomerulonephritis.
  13. (2002). Collagens, collagenbinding heat shock protein 47 and transforming growth factorbeta 1 are induced in cicatricial pemphigoid: possible role(s) in dermal fibrosis.
  14. (1997). Colligin, a collagen binding serpin.
  15. (2009). Converging concepts of protein folding in vitro and in vivo.
  16. (2010). Dietary and genetic evidence for phosphate toxicity accelerating mammalian aging.
  17. (2003). Effect of transforming growth factor-beta1, interleukin-6 and interferon-gamma on the expression of type I collagen, heat shock protein 47, matrix metalloproteinase (MMP)-1 and MMP-2 by fibroblasts from normal gingiva and hereditary gingival fibromatosis.
  18. (2003). Effects of IL-4 on conjunctival fibroblasts: possible role in ocular cicatricial pemphigoid.
  19. (2005). Expression of HSP47, a collagenspecific chaperone, in normal and diseased human liver.
  20. (1998). Expression of the heat shock protein 47 in gentamicin-treated rat kidneys.
  21. (2003). Expression profiles of collagens, HSP47, TGF-beta1, MMPs and TIMPs in epidermolysis bullosa acquisita.
  22. (2003). Factors regulating the progression of hypertensive nephrosclerosis.
  23. (2005). FGF-23, vitamin D and calcification: the unholy triad.
  24. (2009). FGF23-mediated regulation of systemic phosphate homeostasis: is Klotho an essential player?
  25. (2000). Fibrogenesis. V. TGF-beta signaling pathways.
  26. (2009). Fibulin-5 contributes to microfibril assembly in human periodontal ligament cells.
  27. (2008). Genetic suppression of GH-IGF-1 activity, combined with lifelong caloric restriction, prevents agerelated renal damage and prolongs the life span in rats.
  28. Glomerular expression of type III and type IV collagens in benign nephrosclerosis: immunohistochemical and in situ hybridization study.
  29. (2000). Greater than normal expression of the collagen-binding stress protein heat-shock protein-47 in the infarct zone in rats after experimentally-induced myocardial infarction.
  30. (1997). Heat shock and the role of the HSPs during neural plate induction in early mammalian CNS and brain development.
  31. (2005). Heat shock protein 47 and renal fibrogenesis.
  32. (1994). Heat-shock proteins as molecular chaperones.
  33. (2009). Histochemical analysis of renal dysplasia with ureteral atresia.
  34. (2005). Hsp47 a novel collagen binding serpin chaperone, autoantigen and therapeutic target.
  35. (2003). HSP47 as a collagen-specific molecular chaperone: function and expression in normal mouse development.
  36. (1996). Hsp47: a collagen-specific molecular chaperone.
  37. (2000). Hsp47: a molecular chaperone that interacts with and stabilizes correctlyfolded procollagen.
  38. (2008). Immunohistochemical observation of co-expression of E- and N-cadherins in rat organogenesis.
  39. (2004). Immunoinflammatory responses and fibrogenesis.
  40. (1998). Immunolocalization of collagen and collagen-binding heat shock protein 47 in fibrotic lung diseases.
  41. (1994). In situ hybridization analysis of rat lung alpha 1(I) and alpha 2(I) collagen gene expression in pulmonary fibrosis induced by endotracheal bleomycin injection.
  42. (1994). In situ localization of type III and type IV collagenexpressing cells in human diabetic nephropathy.
  43. (2009). In vivo genetic evidence for suppressing vascular and soft-tissue calcification through the reduction of serum phosphate levels, even in the presence of high serum calcium and 1,25-Dihydroxyvitamin D levels.
  44. (2009). In vivo genetic evidence of klotho-dependent functions of FGF23 in regulation of systemic phosphate homeostasis.
  45. (2009). Inactivation of klotho function induces hyperphosphatemia even in presence of high serum fibroblast growth factor 23 levels in a genetically engineered hypophosphatemic (Hyp) mouse model.
  46. (1973). Induction of smooth muscle characteristics in renal interstitial fibroblasts during obstructive nephropathy.
  47. (1996). Intracellular interaction of collagen-specific stress protein HSP47 with newly synthesized procollagen.
  48. (1992). Involvement of the stress protein HSP47 in procollagen processing in the endoplasmic reticulum.
  49. (1999). Life-long dietary restriction modulates the expression of collagens and collagen-binding heat shock protein 47 in aged Fischer 344 rat kidney.
  50. (2006). Life-long suppression of growth hormoneinsulin-like growth factor I activity in genetically altered rats could prevent age-related renal damage.
  51. (2009). Liver fibrosis: challenges of the new era.
  52. (1999). Localization in situ of type VI collagen protein and its mRNA in mesangial proliferative glomerulonephritis using renal biopsy sections.
  53. (2008). Low-dose local kidney irradiation inhibits progression of experimental crescentic nephritis by promoting apoptosis.
  54. (1993). Molecular chaperone functions of heat-shock proteins.
  55. (2009). Multiple pathways for mitochondrial protein traffic.
  56. (2008). Outcome of patients with idiopathic pulmonary fibrosis (IPF) ventilated in intensive care unit.
  57. (2008). Proliferation of HSP47-positive skin fibroblasts in dermatofibroma.
  58. (2003). Pulmonary fibrosis: Cellular and molecular events.
  59. (2009). Pulmonary fibrosis: pathogenesis, etiology and regulation.
  60. (1996). Regulation and function of collagen-specific molecular chaperone, HSP47. Cell Struct.
  61. (2003). Role of collagen-binding heat shock protein 47 and transforming growth factor-beta1 in conjunctival scarring in ocular cicatricial pemphigoid.
  62. (2003). Role of connective tissue growth factor in the pathogenesis of conjunctival scarring in ocular cicatricial pemphigoid.
  63. (1999). Role of glomerular epithelial cell-derived heat shock protein 47 in experimental lipid nephropathy.
  64. (2002). Role of heat shock protein 47 on tubulointerstitium in experimental radiation nephropathy.
  65. (2007). Role of heat shock protein 47, a collagen-binding chaperone, in lacrimal gland pathology in patients with cGVHD.
  66. (2003). Role of TGF-beta in the progression of renal fibrosis.
  67. (2002). Sequencespecific recognition of collagen triple helices by the collagenspecific molecular chaperone HSP47.
  68. (2007). The collagen-specific molecular chaperone HSP47: is there a role in fibrosis? Trends Mol.
  69. (2010). The dualistic role of vitamin D in vascular calcifications. Kidney Int.
  70. (1999). The possible role of colligin/HSP47, a collagen-binding protein, in the pathogenesis of human and experimental fibrotic diseases.
  71. (2001). The renal expression of heat shock protein 47 and collagens in acute and chronic experimental diabetes in rats.
  72. (2008). The upregulation of heat shock protein 47 expression in human buccal fibroblasts stimulated with arecoline.
  73. (1998). Transcriptional activation of the mouse HSP47 gene in mouse osteoblast MC3T3-E1 cells by TGF-beta 1.
  74. (2001). Upregulation of HSP47 and collagen type III in the dermal fibrotic disease, keloid.