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Sulphilimine cross-links in Goodpasture's disease

By R Vanacore, V Pedchenko, G Bhave and B G Hudson


The sulphilimine cross-link of the Goodpasture (GP) autoantigen is a novel molecular mechanism (structural constraint) for conferring immune privilege to a site which otherwise is susceptible to structural changes that induce an immunogenic and pathogenic conformation. Perturbation of the assembly or cleavage of the sulphilimine cross-links could be a key factor in the aetiology of Goodpasture's disease in susceptible individuals

Topics: 15th International Vasculitis and ANCA Workshop. This supplement has been sponsored by the University of North Carolina
Publisher: Blackwell Science Inc
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Provided by: PubMed Central
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