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An Adult Case of Kawasaki Disease in a Pregnant Japanese Woman: A Case Report

By Kyoko Kanno, Hiroyuki Sakai, Masahide Nakajima, Akira Satake, Takayuki Konishi and Hajime Iizuka


Kawasaki disease is an acute febrile disease predominantly seen in young children. We report a case of Kawasaki disease in a 32-year-old pregnant woman. She developed a generalized erythematous skin rash accompanied by high fever. Bilateral conjunctival congestion, tender cervical lymphadenopathy, an edematous lower lip and peripheral edema followed by desquamation were observed. She was successfully treated with aspirin and intravenous gammaglobulin (1 g/kg/day). Her course was not complicated by coronary artery aneurysm and she delivered a healthy baby. To the best of our knowledge, this is the first case of Kawasaki disease in a pregnant woman. We suggest that Kawasaki disease should be included in the differential diagnosis of a generalized, erythematous skin rash accompanied by high fever in adults

Topics: Published: April 2011
Publisher: S. Karger AG
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Provided by: PubMed Central

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  1. (2005). A: Adult Kawasaki disease: report of two cases and literature review. Semin Arthritis Rheum
  2. Activation of the transcription factor, nuclear factor kappa-B, during the estrous cycle and early pregnancy in the pig. Reprod Biol Endocrinol 2010;8:39.
  3. Acute febrile mucocutaneous syndrome with lymphoid involvement with specific desquamation of the fingers and toes in children. Clinical observation of 50 patients.
  4. (1994). al: Adult Kawasaki disease. Report of two cases treated with intravenous gamma globulin.
  5. (2010). C: Kawasaki disease in adults: report of 10 cases. Medicine
  6. D: Kawasaki disease in a postpartum patient.
  7. (2005). Disease Research Committee: Revision of diagnostic guidelines for Kawasaki disease (the 5th revised edition). Pediatr Int
  8. Engel SM: Peripheral blood cytokine profiling during pregnancy and post-partum periods.
  9. I: An adult case of Kawasaki disease in a two-day post-partum woman (in Japanese). Syusanki Igaku 2005;35:1001–1003.
  10. (2008). Ichiyama T: Regulation of proinflammatory cytokine cascade in Kawasaki disease. Nippon Rinsho
  11. (1988). Peripheral blood monocyte/macrophages and serum tumor necrosis factor in Kawasaki disease. Clin Immunol Immunopathol
  12. Pregnancy and delivery in patients with coronary artery lesions caused by Kawasaki disease.
  13. SB: Infliximab treatment for refractory Kawasaki syndrome.
  14. (1996). SK: The optimal dosages of gammaglobulin and aspirin in treating kawasaki disease.
  15. (1999). Successful pregnancy following Kawasaki disease. Obstet Gynecol