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Compartmentalized regulation of autophagy regulators: fine-tuning AMBRA1 by Bcl-2

By Sharon A Tooze and Patrice Codogno


AMBRA1 and Bcl-2 both interact with Beclin 1 and control autophagy as a positive or negative regulator, respectively. A paper in this issue reveals an interaction between AMBRA1 and Bcl-2 at the mitochondrial outer membrane that is relieved upon induction of autophagy or apoptosis allowing AMBRA1 to activate Beclin 1

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Publisher: Nature Publishing Group
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Provided by: PubMed Central
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